Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker RGD This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathological grading and hepatic progenitor cells percentage in HCC rat model. 29429512

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker RGD The point mutations in the Tp53 gene seem to play a role in the development of lung tumors in rats after inhalation exposures to plutonium dioxide. 10564948

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Therapeutic RGD Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. 29546074

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.700 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.600 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.600 Biomarker RGD Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance. 26439224

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker RGD Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. 21854749

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms
0.550 Biomarker RGD Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. 17595763

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis. 24828139

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0022116
Disease: Ischemia
Ischemia
0.500 Biomarker RGD Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model. 18337831

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.400 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206687
Disease: Carcinoma, Endometrioid
Carcinoma, Endometrioid
0.300 Biomarker RGD Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women. 26353976

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.300 Biomarker RGD Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women. 26353976

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0349566
Disease: Squamous cell carcinoma of tongue
Squamous cell carcinoma of tongue
0.300 Biomarker RGD The role of the TP53 gene during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. 20385474

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007120
Disease: Bronchioloalveolar Adenocarcinoma
Bronchioloalveolar Adenocarcinoma
0.280 Biomarker RGD Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. 26059825

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.240 Biomarker RGD Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. 17901943

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated
0.220 Biomarker RGD Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. 26004897

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0040411
Disease: Tongue Neoplasms
Tongue Neoplasms
0.210 Biomarker RGD Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia. 12167434

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0040411
Disease: Tongue Neoplasms
Tongue Neoplasms
0.210 Biomarker RGD p53 expression in various stages of 4-nitroquinoline 1-oxide induced carcinoma in the rat tongue. 9485768

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0042995
Disease: Vulvar Neoplasms
Vulvar Neoplasms
0.200 Biomarker RGD [Establishment of a rat model of dimethylbenzanthracene-induced vulvar squamous intraepithelial lesions]. 30514679

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Hepatoblastoma Caused By Somatic Mutation
0.200 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
0.200 Biomarker RGD These findings suggested that neonatal BPD caused impaired cognitive function and neuron apoptosis in hippocampus via p53 and HIF-1α. 26431790

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of connective and other soft tissue, site unspecified
0.200 ModifyingMutation RGD Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. 21854749

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0011263
Disease: Multi-infarct dementia
Multi-infarct dementia
0.200 Biomarker RGD Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. 18083315

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0011269
Disease: Dementia, Vascular
Dementia, Vascular
0.200 Biomarker RGD The expression of BCL-2 and HSP70 proteins were increased, while BAX and P53 decreased after ginsenoside Rg2 (2.5, 5 and 10mg/kg) and nimodipine (50 microg/kg) treatment compared with the VD group. 18083315

2008