Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.300 Biomarker RGD The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats. 15578039

2005
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.300 Biomarker RGD DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats. 15667904

2005
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.300 Biomarker RGD The effect of DA-8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction. 15920460

2005
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.250 Biomarker RGD Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. 17339532

2007
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.240 Biomarker RGD Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. 19729580

2009
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0162770
Disease: Right Ventricular Hypertrophy
Right Ventricular Hypertrophy 		0.220 Biomarker RGD Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. 17606845

2007
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C1384666
Disease: hearing impairment
hearing impairment 		0.200 Therapeutic RGD cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. 22270721

2012
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity. 19542492

2009
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.200 Biomarker RGD Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats. 19881228

2009
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0021368
Disease: Inflammation
Inflammation 		0.200 Biomarker RGD In the present study, the effect of sildenafil, a potent inhibitor of PDE5 that selectively degrades cyclic guanosine 3',5'-monophosphate (cGMP), on acrolein-induced inflammation and mucus production in rat airways was examined. 19129291

2009
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. 19474186

2009
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.200 Biomarker RGD Impact of a long-term sildenafil treatment on pressor response in conscious rats with insulin resistance and hypertriglyceridemia. 18787522

2008
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.200 Biomarker RGD The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with suramin treated rats and the effect of phosphodiesterase-5 (PDE5) inhibitor on these responses. 18538317

2008
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.200 Biomarker RGD Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat. 17610866

2007
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.200 Biomarker RGD Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat. 17610866

2007
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0243000
Disease: Impotence, Vasculogenic
Impotence, Vasculogenic 		0.200 Biomarker RGD Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat. 17287493

2007