Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Therapeutic CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Therapeutic CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. 23834033

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Therapeutic CTD_human Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. 23834033

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Therapeutic CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820

2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Therapeutic CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189

2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189

2011