Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.340 Biomarker CTD_human COX-2 is overexpressed in adenomas and colorectal cancers, and COX-2-specific inhibitors have been shown to inhibit intestinal polyps in Apc(Delta716) mice more effectively than dual COX-1/COX-2 inhibitors such as sulindac. 11507063

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.340 Biomarker CTD_human Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. 11245490

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.340 Biomarker CTD_human While the exact mechanism(s) for this antitumor activity of p-XSC remains to be elucidated, it appears that modulation of beta-catenin expression and COX-2 activity is associated with inhibition of intestinal polyps. 10753194

2000