Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression LHGDN Defects in TNFalpha signalling pathways rather than distribution of TNF receptors (TNFRs) probably explain the enhanced apoptosis in SLE. 19110660

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation LHGDN The -863A allele of TNF-alpha gene and the extended haplotype of -863A, -308G, -238G can be used as a genetic marker for SLE susceptibility in Thai populations. 18001298

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation LHGDN These findings suggest that specific TNF variants may identify SLE patients who are at particularly high risk of developing pneumonia. 17665457

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 Biomarker LHGDN Increased expression of membrane TNF-alpha on activated peripheral CD8+ T cells in systemic lupus erythematosus. 16596274

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation LHGDN In summary, this meta-analysis demonstrates that the TNF-alpha promoter -308 A/G polymorphism may confer susceptibility to SLE, especially in European-derived population. 16418737

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression LHGDN Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs. 16507146

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression LHGDN Finally, associations with cell death and CD95 receptors suggest that TNF may be pathogenic in SLE. 11958572

2002