Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 AlteredExpression LHGDN Ovarian cancer tissues were obtained from 61 patients: 45 platinum-sensitive and 16 platinum-resistant. hMLH1 and hMSH2 proteins expression was evaluated by immunohistochemistry, with the use of mouse monoclonal antibodies clone 14 for hMLH1 and clone FE11 for hMSH2. 19175039

2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 GeneticVariation LHGDN The G>A nt-93 variant of the MLH1 gene is associated with an increased risk of invasive ovarian cancer. 18405947

2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 PosttranslationalModification LHGDN These data support the clinical relevance of acquired hMLH1 methylation and concomitant loss of DNA MMR after chemotherapy of ovarian cancer patients. 15240532

2004
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 GeneticVariation LHGDN 1) Coding DNA instability is likely to be a very rare event in OC and, therefore, may not significantly contribute to the development of OC, and 2) the high frequency of LOH at hMLH1 observed in our ovarian tumors suggests that further investigation is needed to determine if such a trend exists in other mismatch DNA repair and/or critical genes. 12014680

2002