Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD This seems to suggest that sPLA2 and cPLA2 play opposing roles in asthma pathophysiology and the possibility of a negative feedback between the two isoenzymes. 15557087

2005

Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD However, growing evidence raises the possibility that in airways and asthma-related inflammatory cells (eosinophils, basophils), the production of the bronchoconstrictor cysteinyl leukotrienes (CysLT) is linked exclusively to sPLA2, whereas the bronchodilator prostaglandin PGE2 is produced by cPLA2. 15557087

2005

Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD This study demonstrates, for the first time in vivo, a negative feedback between sPLA2 and cPLA2 and assigns opposing roles for these enzymes in asthma pathophysiology: sPLA2 activation induces production of the bronchoconstrictor CysLT and suppresses cPLA2 expression and the subsequent production of the bronchodilator PGE2. 15557087

2005