DisGeNET - a database of gene-disease associations

Source: RGD

Disease: Cholestasis ×

Gene: SLCO1B3 ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	28234
Gene Symbol:	SLCO1B3

SLCO1B3

CUI:	C0008370
Disease:	Cholestasis

Cholestasis

0.220

Biomarker

RGD

Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2.

2007