Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Thresholds for identifying ambulatory hypertension (daytime systolic BP [SBP]/diastolic BP [DBP] ≥135/85 mm Hg, 24-hour SBP/DBP ≥130/80 mm Hg, and nighttime SBP/DBP ≥120/70 mm Hg) have been derived from European, Asian, and South American populations. 28428231

2017

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE The participants were classified into three groups: hypertension (HTN), high normal BP, and normal BP, and also into SBP and DBP quintiles. 29210861

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE Each interquartile increment in walkability was associated with the lower blood pressure outcomes of DBP (β = -0.358, 95% CI: -0.42, -0.29 mmHg), SBP (β = -0.833, 95% CI: -0.95, -0.72 mmHg) as well as reduced hypertension risk (RR = 0.970, 95% CI: 0.96, 0.98). 29398408

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE In addition, we found that systolic pressure (SBP; 129.32 ± 14.86 mmHg, <i>p</i> = 0.041), body mass index (BMI; 22.54 ± 2.71, <i>p</i> = 0.046), and low-density lipoprotein (LDL; 3.09 ± 0.98 mmol/L, <i>p</i> = 0.048) in the subjects with PES were significantly higher than those measurements in the CN subjects (SBP; 122.06 ± 10.55 mmHg; BMI; 20.24 ± 2.13; LDL; 2.91 ± 0.76 mmol/L), and there was a significant negative correlation between an increased adult hypertension risk and a shorter LTL. 29085308

2017

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE In 'fit' participants, the decline in SBP was 12.4 (95% confidence interval 11.9-13.0) mmHg/decade in those treated for hypertension and 8.5 (7.8-9.1) mmHg in those not treated. 28441696

2017

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE ERA significantly reduced 24-h ambulatory blood pressure and sitting blood pressure in patients with hypertension [5 trials, 24-h SBP: WMD -7.65 (-8.95 to -6.36), 24-h DBP: WMD -5.92 (-7.50 to -4.33); 18 trials, SBP: WMD -6.12 (-7.87 to -4.36), DBP: WMD -3.81 (-4.82 to -2.80)]. 27808564

2017

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE In this cross-sectional study, 200 outpatients (161 women, 39 men) with essential HTN (systolic blood pressure [SBP] ≥ 140 mmHg and diastolic blood pressure [DBP] ≥ 90 mmHg) were recruited from August to November 2012. 28318434

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE In addition, short-term exposures to four (PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, NO<sub>2</sub>), two (PM<sub>2.5</sub> and SO<sub>2</sub>), and four air pollutants (PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, and NO<sub>2</sub>), were significantly associated with hypertension (ORs: 1.05-1.10), SBP (β values: 0.53-0.75 mmHg) and DBP (β values: 0.15-0.64 mmHg), respectively. 29331891

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Hypertension was defined as SBP at least 130 mmHg or DBP at least 80 mmHg, taking antihypertensive medicine or self-report. 31356404

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE We assessed the role of SBP VVV on the development of CKD in patients with type 2 diabetes (T2D) and hypertension in real life. 30817462

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Further logistic analysis indicated that the irisin level was positively correlated with SBP and an independent predictor for hypertension after adjustment. 31133682

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE These trials - SPYRAL OFF-MED, RADIANCE SOLO and SPYRAL ON-MED - using newer technologies, demonstrate a 5-10 mmHg incremental reduction in ambulatory SBP from RDN against sham-control, in patients with mild-to-moderate hypertension taking 0-3 drugs. 31268917

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE An increase of 0.1 in NDVI corresponded to a reduction in SBP of 1.39 mmHg (95% CI: 1.86, -0.93) and lower odds of hypertension (OR = 0.76, 95% CI: 0.69, 0.82). 31672364

2020

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Participants with hypertension but without diabetes (N = 1167) were randomized to an SBP target below 120 mm Hg (intensive treatment) vs a target below 140 mm Hg (standard treatment). 31840813

2020

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE Stage 2 hypertension (SBP/DBP ≥ 140/90 mmHg) showed significant associations with cardiovascular disease and all-cause mortality, while elevated blood pressure (SBP 120-129 mmHg and DBP < 80 mmHg) showed null associations. 31288541

2020

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE Forty-one patients with and 82 patients without intradialytic hypertension (intradialytic SBP rise ≥10 mm Hg to > 150 mm Hg) matched in a 1: 2 ratio for age, sex, and hemodialysis vintage were included. 30347395

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE Prespecified analyses of the Enhanced Control of Hypertension and Thrombolysis Stroke Study for patients enrolled in both arms: (i) low-dose (0.6 mg/kg body weight) or standard-dose (0.9 mg/kg) alteplase and (ii) intensive (target systolic BP [SBP] 130-140 mm Hg) or guideline-recommended (target SBP <180 mm Hg) BP management. 31812956

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE The impact of DBP on the risk of developing hypertension compared with optimal BP (SBP <120 mm Hg and DBP <80 mm Hg) was significantly greater than that of SBP in subjects younger than 50 years (hazard ratios, 17.5 for isolated diastolic high-normal vs 10.5 for isolated systolic high-normal [P<.001]; 8.0 for isolated diastolic normal vs 4.1 for isolated systolic normal [P<.001]). 28444926

2017

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Wrist circumference, a marker of insulin resistance, is associated with increased SBP in overweight/obese children and adolescents, suggesting a role of insulin resistance in the pathogenesis and development of hypertension. 29335612

2018

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE This randomized-cross-over study included 38 patients (age: 60.4 ± 11.1 years, male: 65.8%) with intradialytic hypertension (intradialytic-SBP increase ≥ 10 mmHg at ≥4 over 6 consecutive sessions). 30622317

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Childhood hypertension and elevated blood pressure were defined as SBP and/or DBP ≥95th and ≥90th age- and gender-specific percentile, respectively. 31826379

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE The genetic risk score, calculated as the sum of BP-increasing alleles of FGF5-rs16998073, CYP17A1-rs11191548, CYP17A1-rs1004467 and MTHFR-rs17367504, was significantly associated with increased SBP (1.16 mmHg/allele, P = 9.01E-5), DBP (0.51 mmHg/allele, P = 4.40E-4) and hypertension risk (OR = 1.22/allele, P = 2.74E-7). 20852445

2011

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Participants in the bottom 30% (ie, SBP decreased on standing) were significantly older, had a greater prevalence of hypertension and peripheral vascular disease, had higher values of SBP, and had more cigarette-years of smoking. 10334798

1999

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE In a univariate logistic regression analysis hypertension and clinic SBP were not associated with revealed symptoms. 31157741

2019

Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE Pre- and undiagnosed-hypertension was defined as systolic blood pressure/ diastolic blood pressure (SBP/DBP) of 120-139/80-89 mm Hg and SBP⩾140 mm Hg and/or DBP⩾90 mm Hg, respectively, in participants without a history of hypertension and use of antihypertensive medication. 27654328

2017