Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human The role of the parathyroid glands in adrenocorticotrophin-induced hypertension in the rat. 10513829

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970

2005

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Changes in pressor responsiveness do not explain ACTH hypertension. 3015460

1986

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat. 11518849

2001

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Hormonal background of the hypertension and fluid derangements associated with adrenocorticotrophic hormone treatment of infants. 2551692

1989

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human In man ACTH produces systolic hypertension which can be reproduced by infusion of cortisol, but not deoxycorticosterone, at rates appropriate for conditions of ACTH stimulation. 3001556

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Role of the renal medulla in adrenocorticotrophin-induced hypertension in rats. 1334993

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Haemodynamic mechanisms of corticotropin (ACTH)-induced hypertension in the rat. 10658937

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat. 11703388

2001

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human The role of this increased pressor responsiveness in ACTH/steroid-induced hypertension remains to be determined. 1321309

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophin-induced hypertension in rats. Role of progesterone and digoxin-like substances. 8136112

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Alterations in osmotic but not pressor responses to ACTH by optic recess lesions in sheep. 6279500

1982

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human We hypothesized that ACTH-induced hypertension in the rat is characterized by increased EPO production. 15110907

2004

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats. 1316127

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835

2006

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human However, when RAP is not allowed to rise, ACTH is associated with sodium retention and severe systemic hypertension, suggesting that the natriuretic effects of ACTH are caused by increased RAP and that the natriuresis blunts the chronic hypertensive effects of ACTH. 2849322

1988

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. 15554453

2004

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. 11193135

2000

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Acute glucocorticoid (corticosterone) hypertension in the rate is significantly attenuated by neomycin administration (Honour 1981), as is ACTH-induced hypertension is the same species (Honour & Kent 1981) presumably by altering gut bacterial steroid metabolism. 6097376

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Potentiation of ACTH hypertension in man with salt loading. 2992854

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Role of the sympathetic nervous system in the onset of hypertension in the rat: the effect of 6-OH-dopamine. 1649024

1991

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970

2005