Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Effects of bromocriptine on blood pressure and plasma beta-endorphin in spontaneously hypertensive rats. 6274577

1981

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Vasodilator prostanoids and ACTH-dependent hypertension. 6135010

1983

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan. 10474778

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. 12872045

2003

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835

2006

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. 11193135

2000

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the rat. 12887135

2003

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human These studies suggest that a steroid other than aldosterone, 18-OH-DOC, or DOC may be the cause of the ACTH-induced hypertension in this patient. 187612

1976

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Exaggerated natriuresis in ACTH hypertension in sheep. 216942

1978

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Influence of somatostatin analogue (SMS 201-995, octreotide) on blood pressure in adrenocorticotrophin (ACTH) treated rats: role of hyperinsulinaemia in ACTH hypertension. 8261660

1993

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Dexamethasone-responsive hypertension in young women with suppressed renin and aldosterone. 76749

1978

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man. 2822310

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Potentiation of ACTH hypertension in man with salt loading. 2992854

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Telemetric monitoring of adrenocorticotrophin-induced hypertension in mice. 11560123

2001

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Based on the various biological effects of ACTH different explanations are proposed: oedema or deposition of glycogen in the myocardial tissue, hyperinsulinism, arterial hypertension and increased inotropic stimulus. 6088243

1984

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Overall, the data establish that the alpha(2)-Na(+)-K(+)-ATPase ouabain-binding site is of central importance in the development of ACTH-induced hypertension. 18487447

2008

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Effects of bromocriptine on blood pressure and plasma beta-endorphin in spontaneously hypertensive rats. 6274577

1981

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man. 2822310

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human These studies suggest that a steroid other than aldosterone, 18-OH-DOC, or DOC may be the cause of the ACTH-induced hypertension in this patient. 187612

1976

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Inhibition of NO synthesis has an additive effect on hypertension induced by ACTH in conscious rats. 1330390

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human In man ACTH produces systolic hypertension which can be reproduced by infusion of cortisol, but not deoxycorticosterone, at rates appropriate for conditions of ACTH stimulation. 3001556

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Cushing's disease in dogs and humans. 19153526

2009

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic CTD_human Cushing's syndrome secondary to ACTH-secreting Wilms' tumor. 4367732

1974