Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4316903
Disease: Absence Seizures
Absence Seizures 		0.300 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Therapeutic CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker PSYGENET DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. 25462909

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker PSYGENET The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin. 19884906

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker PSYGENET Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice. 15547455

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker PSYGENET These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP gene promoter region in alcohol dependence. 25462909

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. 28242381

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Therapeutic CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.300 Therapeutic CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Therapeutic CTD_human Leptin, an adipocytokine involved in cell survival and in learning, has been demonstrated to regulate Abeta production and tau hyperphosphorylation in transgenic mice for AD. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Therapeutic CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0003865
Disease: Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced 		0.300 Biomarker CTD_human Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. 15142272

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0971858
Disease: Arthritis, Collagen-Induced
Arthritis, Collagen-Induced 		0.300 Biomarker CTD_human Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. 15142272

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0993582
Disease: Arthritis, Experimental
Arthritis, Experimental 		0.300 Biomarker CTD_human Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. 15142272

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0751123
Disease: Atonic Absence Seizures
Atonic Absence Seizures 		0.300 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 Biomarker CTD_human Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? 17347881

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0241910
Disease: Autoimmune Chronic Hepatitis
Autoimmune Chronic Hepatitis 		0.300 Biomarker CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. 21353530

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0221765
Disease: Chronic schizophrenia
Chronic schizophrenia 		0.320 Biomarker PSYGENET Leptin G2548A polymorphism was genotyped in 102 Chinese Han inpatients with chronic schizophrenia treated with clozapine. 17502770

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0234535
Disease: Clonic Seizures
Clonic Seizures 		0.300 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.320 Biomarker CTD_human Leptin promotes the growth of Colon 38 cancer cells and interferes with the cytotoxic effect of fluorouracil in vitro. 17354198

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.300 Biomarker CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672

1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.300 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4048158
Disease: Convulsions
Convulsions 		0.300 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0751494
Disease: Convulsive Seizures
Convulsive Seizures 		0.310 Therapeutic CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459

2008