Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. 29967158

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Therapeutic CTD_human Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. 29967158

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. 28242381

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker CTD_human Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. 28242381

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Therapeutic CTD_human IL-33 Drives Augmented Responses to Ozone in Obese Mice. 27472835

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human IL-33 Drives Augmented Responses to Ozone in Obese Mice. 27472835

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1262477
Disease: Weight decreased
Weight decreased 		0.300 Biomarker CTD_human Bardoxolone methyl prevents obesity and hypothalamic dysfunction. 27417254

2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0556385
Disease: Craving for alcohol
Craving for alcohol 		0.300 Biomarker PSYGENET DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. 25462909

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.300 Biomarker CTD_human ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats. 25205467

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Therapeutic CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Therapeutic CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0085602
Disease: Polydipsia
Polydipsia 		0.300 Biomarker CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker CTD_human Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. 24150608

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Therapeutic CTD_human Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. 24150608

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0021361
Disease: Female infertility
Female infertility 		0.300 Biomarker CTD_human Adiponectin and leptin systems in human endometrium during window of implantation. 22265003

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0038279
Disease: Sterility, Postpartum
Sterility, Postpartum 		0.300 Biomarker CTD_human Adiponectin and leptin systems in human endometrium during window of implantation. 22265003

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0341869
Disease: Subfertility, Female
Subfertility, Female 		0.300 Biomarker CTD_human Adiponectin and leptin systems in human endometrium during window of implantation. 22265003

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0917730
Disease: Female sterility
Female sterility 		0.300 Biomarker CTD_human Adiponectin and leptin systems in human endometrium during window of implantation. 22265003

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1136382
Disease: Sclerocystic Ovaries
Sclerocystic Ovaries 		0.300 Biomarker CTD_human The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients. 22381227

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Therapeutic CTD_human Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. 21561152

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. 21561152

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567

2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0241910
Disease: Autoimmune Chronic Hepatitis
Autoimmune Chronic Hepatitis 		0.300 Biomarker CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906

2011