Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0000832
Disease: Abruptio Placentae
Abruptio Placentae 		0.310 Biomarker CTD_human We conclude that the presence of the Glu298Asp eNOS gene variant could be a marker of increased risk of developing placental abruption. 11354626

2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker CTD_human Association between Alzheimer's disease and the NOS3 gene. 10514107

1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker CTD_human Genetic association between endothelial nitric oxide synthase and Alzheimer disease. 16813604

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Biomarker CTD_human Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl2-induced acute renal failure. 9788586

1998
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker CTD_human Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl2-induced acute renal failure. 9788586

1998
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet. 14871415

2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. 19478208

2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. 11696579

2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. 15490108

2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. 22933112

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. 18266981

2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Biomarker CTD_human Genetic association between endothelial nitric oxide synthase and Alzheimer disease. 16813604

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Biomarker CTD_human Association between Alzheimer's disease and the NOS3 gene. 10514107

1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.350 Biomarker CTD_human Genetic association between endothelial nitric oxide synthase and Alzheimer disease. 16813604

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.350 Biomarker CTD_human Association between Alzheimer's disease and the NOS3 gene. 10514107

1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.500 Biomarker CTD_human Association between Alzheimer's disease and the NOS3 gene. 10514107

1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.500 Biomarker CTD_human The Glu/Glu genotype at the Glu298Asp variant of the endothelial nitric oxide synthase (NOS3) gene has been tested for association with AD in several Caucasian and Asian populations, with conflicting results. 16813604

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Biomarker CTD_human Genetic association between endothelial nitric oxide synthase and Alzheimer disease. 16813604

2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Biomarker CTD_human Association between Alzheimer's disease and the NOS3 gene. 10514107

1999