Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0005398
Disease: Cholestasis, Extrahepatic
Cholestasis, Extrahepatic 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0019209
Disease: Hepatomegaly
Hepatomegaly 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0238065
Disease: Secondary Biliary Cholangitis
Secondary Biliary Cholangitis 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0403824
Disease: Teratozoospermia
Teratozoospermia 		0.300 Biomarker CTD_human Level of NO/nitrite and 3-nitrotyrosine in seminal plasma of infertile men: Correlation with sperm number, motility and morphology. 29983398

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0403825
Disease: Globozoospermia
Globozoospermia 		0.300 Biomarker CTD_human Level of NO/nitrite and 3-nitrotyrosine in seminal plasma of infertile men: Correlation with sperm number, motility and morphology. 29983398

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C1306571
Disease: Hepatic Insufficiency
Hepatic Insufficiency 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.300 Biomarker CTD_human Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease. 26207612

2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0848676
Disease: Subfertility, Male
Subfertility, Male 		0.300 Biomarker CTD_human Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study. 25517965

2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0917731
Disease: Male sterility
Male sterility 		0.300 Biomarker CTD_human Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study. 25517965

2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. 22933112

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker CTD_human Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. 22933112

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C1527303
Disease: Chronic Airflow Obstruction
Chronic Airflow Obstruction 		0.300 Biomarker CTD_human Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men. 21843929

2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.300 Biomarker CTD_human Folate pathway and nonsyndromic cleft lip and palate. 21254359

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.300 Biomarker CTD_human Folate pathway and nonsyndromic cleft lip and palate. 21254359

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205643
Disease: Carcinoma, Cribriform
Carcinoma, Cribriform 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205644
Disease: Carcinoma, Granular Cell
Carcinoma, Granular Cell 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143

2011