×
Entrez Id: 1628
Gene Symbol: DBP
DBP
Polycystic Ovary Syndrome
0.020
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP : diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries ; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome ; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 6822
Gene Symbol: SULT2A1
SULT2A1
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS : dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries ; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 6046
Gene Symbol: BRD2
BRD2
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH : follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries ; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome ; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome ; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP : systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 5120
Gene Symbol: PCOS1
PCOS1
Polycystic Ovary Syndrome
0.040
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO : polycystic ovaries ; PCO : polycystic ovary ; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1
Polycystic Ovary Syndrome
0.010
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome ; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP : systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
SELENBP1
Polycystic Ovary Syndrome
0.010
Biomarker
BEFREE
<b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary ; PCOS: polycystic ovary syndrome ; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP : systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D.
30958034 2019
×
Entrez Id: 9469
Gene Symbol: CHST3
CHST3
Polycystic Ovary Syndrome
0.040
Biomarker
BEFREE
<b>Abbreviations:</b> 3β-HSD : 3β-hydroxysteroid dehydrogenase; CAP1: cyclase-associated protein 1; DCN: decorin; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1: insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome ; RIA: radioimmunoassay; ROR1: receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4.
31099269 2019
×
Entrez Id: 10487
Gene Symbol: CAP1
CAP1
Polycystic Ovary Syndrome
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3β-HSD: 3β-hydroxysteroid dehydrogenase; CAP1 : cyclase-associated protein 1; DCN: decorin; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1: insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome ; RIA: radioimmunoassay; ROR1: receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4.
31099269 2019
×
Entrez Id: 1634
Gene Symbol: DCN
DCN
Polycystic Ovary Syndrome
0.020
Biomarker
BEFREE
<b>Abbreviations:</b> 3β-HSD: 3β-hydroxysteroid dehydrogenase; CAP1: cyclase-associated protein 1; DCN : decorin ; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1: insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome ; RIA: radioimmunoassay; ROR1: receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4.
31099269 2019
×
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> 3β-HSD: 3β-hydroxysteroid dehydrogenase; CAP1: cyclase-associated protein 1; DCN: decorin; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1 : insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome ; RIA: radioimmunoassay; ROR1: receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4.
31099269 2019
×
Entrez Id: 4919
Gene Symbol: ROR1
ROR1
Polycystic Ovary Syndrome
0.010
AlteredExpression
BEFREE
<b>Abbreviations:</b> 3β-HSD: 3β-hydroxysteroid dehydrogenase; CAP1: cyclase-associated protein 1; DCN: decorin; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1: insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome ; RIA: radioimmunoassay; ROR1 : receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4.
31099269 2019
×
Entrez Id: 268
Gene Symbol: AMH
AMH
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> PCO : polycystic ovaries ; HCG: human chorionic gonadotropin; GV: germinal vesicle; MII: metaphase II; IVM: <i>in vitro</i> maturation; IVF: <i>in vitro</i> fertilization; IVC: <i>in vitro</i> culture: MVC: microvibration culture; SC: static culture; ICSI: intracytoplasmic sperm injection; IVM/F-ET: IVM and fertilization-embryo transfer; AMH : anti-Mullerian hormone; OHSS: ovarian hyperstimulation syndrome.
31002532 2019
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Polycystic Ovary Syndrome
0.100
AlteredExpression
BEFREE
<b>Conclusion</b> Relative to the control group, endometrial flushing fluid TNF-α levels were significantly higher in endometrioma patients and IL-2 levels were significantly lower in PCOS , leiomyoma and endometrioma patients.
31148852 2019
×
Entrez Id: 3558
Gene Symbol: IL2
IL2
Polycystic Ovary Syndrome
0.010
AlteredExpression
BEFREE
<b>Conclusion</b> Relative to the control group, endometrial flushing fluid TNF-α levels were significantly higher in endometrioma patients and IL-2 levels were significantly lower in PCOS , leiomyoma and endometrioma patients.
31148852 2019
×
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
Polycystic Ovary Syndrome
0.010
Biomarker
BEFREE
<b>Conclusion:</b> Our data suggest that Gremlin 1 may be the key regulator in the pathogenesis of PCOS .
30712421 2019
×
Entrez Id: 3814
Gene Symbol: KISS1
KISS1
Polycystic Ovary Syndrome
0.090
AlteredExpression
BEFREE
<b>Conclusion:</b> Overall, kisspeptin levels are higher in the PCOS population, which supports the hypothesis that an over-active KISS1 system leads to enhanced HPG-axis activity, thereby causing irregular menstrual cycles and excessive androgen release in PCOS women.
31156550 2019
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
<b>Conclusions:</b> This <i>post-hoc</i> analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS .
31293514 2019
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Polycystic Ovary Syndrome
0.030
Biomarker
BEFREE
<b>Conclusions:</b> This <i>post-hoc</i> analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS .
31293514 2019
×
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
Polycystic Ovary Syndrome
0.020
GeneticVariation
BEFREE
<b>Results:</b> The frequencies of the <i>PL</i> + <i>LL</i> genotype (14.1 vs. 8.4%) and <i>L</i> allele (7.3 vs. 4.4%) of <i>GPx1 P198L</i> polymorphism were significantly higher in patients with PCOS than in control subjects.
31781040 2019
×
Entrez Id: 5241
Gene Symbol: PGR
PGR
Polycystic Ovary Syndrome
0.280
AlteredExpression
BEFREE
<i>In vivo</i> and <i>in vitro</i> studies of the effects of metformin on the regulation of the uterine P4 signaling pathway under PCOS conditions showed that metformin directly inhibits the expression of PGR and ER along with the regulation of several genes that are targeted dependently or independently of PGR -mediated uterine implantation.
29535146 2018
×
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
Polycystic Ovary Syndrome
0.100
Biomarker
BEFREE
(i) An exploratory cross-sectional study investigating association of potential cardiometabolic risk markers (PCOS status, anthropometric measures, hsCRP, HOMA-IR, SHBG , testosterone) with indices of glucose (frequently sampled intravenous glucose tolerance test) and lipid metabolism (postprandial studies and lipoprotein particle size) in 61 women with (n = 29) and without (n = 32) PCOS ; (ii) a cross-sectional study in 103 PCOS women and 102 BMI-matched controls to explore if between-group differences in indices of lipid and glucose metabolism persist after adjusting for WC.
29285778 2018
×
Entrez Id: 7976
Gene Symbol: FZD3
FZD3
Polycystic Ovary Syndrome
0.010
AlteredExpression
BEFREE
(iii) Conversely, inhibition of FZD3 expression exhibited a therapeutic effect on estrogen synthesis in PCOS CCs.
28709873 2017
SERPINE1
Polycystic Ovary Syndrome
0.100
AlteredExpression
BEFREE
2) PCOS women have higher levels of PAI-1 compared with the control group.
15191349 2004
SERPINE1
Polycystic Ovary Syndrome
0.100
GeneticVariation
BEFREE
4G/5G polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome .
17661167 2007