Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 Biomarker GENOMICS_ENGLAND

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE 11 patients with confirmed CDH1 mutation who were found to have HDGC in a prophylactic total gastrectomy were collected. 29307626

2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE 25-30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline mutations of the CDH1 (E-cadherin) gene. 20591882

2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome caused, in 30-40% of cases, by germline mutations of the E-cadherin/CDH1 gene. 15141383

2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is defined by germline mutations in the E-cadherin gene, CDH-1. 15753528

2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome defined by germline mutation of the E-cadherin gene (CDH-1). 16527687

2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer is a rare autosomal dominant cancer susceptibility syndrome caused by germline E-cadherin (CDH1) mutations in 40% of cases with a high degree of penetrance. 18391748

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is caused by germline E-cadherin (CDH1) mutations in 25-40% of tested families. 18825658

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) results from truncating mutations of the CDH1 (E-cadherin) gene. 19408054

2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer is a cancer syndrome caused by germline mutations in the gene for the cell adhesion protein E-cadherin (CDH1). 19432899

2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice. 20373070

2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC), an autosomal dominant cancer susceptibility syndrome, is largely attributable to germline mutations and deletions in the gene encoding E-cadherin, CDH1. 20534996

2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is characterized as an autosomal dominant cancer susceptibility syndrome largely attributable to germline mutations and deletions in the gene encoding E-cadherin, CDH1. 21872467

2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is a relatively rare disorder, with a mutated CDH1 gene as the only known cause. 22388873

2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1. 24037103

2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. 25979631

2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. 26759166

2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer has an early onset and poor prognosis, therefore, individuals who carry a pathogenic (CDH1) mutation in the E-cadherin gene (CDH1) are offered endoscopic surveillance and advised to undergo prophylactic total gastrectomy (PTG) in their early to mid-twenties. 27256430

2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE HDGC is predominantly caused by germline mutations in CDH1 and in a minority by mutations in other genes, including CTNNA1. 27573781

2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) syndrome is caused by germline mutations in the CDH1 gene and carries a lifetime gastric cancer risk of approximately 70 % in men and 56 % in women. 27752808

2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is associated with E-cadherin 1 (<i>CDH1</i>) germline mutations. 28789394

2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant syndrome characterised by multigenerational diffuse gastric cancer, and is mainly caused by germline alterations in the CDH1 gene. 30014492

2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE E-cadherin gene mutations in association with familial gastric cancer is a new disease for which prophylactic surgery must be considered. 11602891

2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE CDH1 gene mutations are not present in Polish families with HDGC defined by the modified clinical criteria. 20842455

2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.800 GeneticVariation BEFREE CDH1 germline alterations occur in about 40% of hereditary diffuse gastric cancer (HDGC) families. 21106365

2011