|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Reprogramming with octamer-binding protein 4 and Jun dimerization protein 2 can inhibit tumorigenesis by switching off BMP7.Stem Cells 2017;35:2115-2128.
|
28782268 |
2017 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Silencing FOXM1 inhibited the expression of Nanog, Oct4, and Sox2 in LCSCs by decreasing the expression of ALDH2. in vivo experiment, silencing FOXM1 suppressed tumorigenesis of LCSCs by decreasing the expression of ALDH2.
|
31580537 |
2020 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Studies revealed that the methylation level in the basal promoter region of OCT3 was associated with OCT3 expression level and tumorigenesis capability in various prostate cancer cell lines.
|
22231567 |
2013 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
The OSCC cell line H103 which was able to be reprogrammed into an iPSC like state showed high expression of Oct4, Sox2 and Nanog at late passage and may provide a potential iPSC model to study multi-stage oncogenesis in OSCC.
|
28417059 |
2017 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
The strong expression of Oct4 and Nanog in metaplastic ducts and Oct4 expression preceding Ras mutation suggests that these homeobox transcription factors are associated with the early stage of pancreatic cancer carcinogenesis and may play an important role in that process.
|
20173672 |
2010 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
These data are consistent with the cancer stem cell model of tumorigenesis in osteosarcoma and implicate a functional link between the capacity to activate an exogenous Oct-4 promoter and tumor formation.
|
19584295 |
2009 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression.
|
12841847 |
2003 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
These results suggest three points: (1) Oct4 might be treated as a new target for the treatment of cervical cancer, (2) we could not inhibit the expression of Oct4 by DNA demethylation, and (3) HPV virus might initiate cervical carcinogenesis by upregulation of Oct4 expression.
|
21674242 |
2011 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Though Oct4 and Nanog are homebox transcription factors essential to the self-renewal of stem cells and are expressed in several cancers, the role of Oct4/Nanog signaling in tumorigenesis is still elusive.
|
21159654 |
2010 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Through an integrative approach combining our Oct4 chromatin-immunoprecipitation sequencing and ENCODE datasets, we identified the genome-wide binding regions of Oct4 in lung cancer at promoter and enhancer of numerous genes involved in critical pathways which promote tumorigenesis.
|
25609695 |
2015 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor.
|
26418365 |
2016 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs).
|
22014056 |
2011 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
To investigate whether Oct4 and Nanog play crucial role in maintaining the stemness of PCSCs, double knockdown of Oct4 and Nanog demonstrated that Oct4 and Nanog significantly reduced proliferation, migration, invasion, chemoresistance, and tumorigenesis of PCSCs in vitro and in vivo.
|
23872274 |
2013 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
To understand the molecular mechanism by which OCT4 and GDF3 function in tumorigenesis as well as stemness, we investigated the transcriptional regulation of GDF3 mediated by OCT4 in human embryonic carcinoma (EC) NCCIT cells, which are pluripotent stem cells of TGCTs.
|
27803451 |
2016 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
TSSC3 was expressed at a low level in T-ICs, while overexpression of TSSC3 could efficiently downregulate the expression of stem cell markers Nanog, Oct4 and Sox2 in T-ICs and decrease the clone formation rate, as well as downregulate tumorigenesis in MThFOB1.19 cells, supporting a suppressive role for TSSC3 in OS T-ICs.
|
22610481 |
2012 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
With the availability of normal adult human stem cells, tests for the expression of Oct3/4 gene and the stem cell theory in human carcinogenesis became possible.
|
17261754 |
2006 |