×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Drug-Induced Liver Disease
0.540
Biomarker
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750
2011
×
Entrez Id:
761
Gene Symbol:
CA3
CA3
Drug-Induced Liver Disease
0.500
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
28762043
2018
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam.
28844483
2017
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
"Serum microRNA signatures as ""liquid biopsies"" for interrogating hepatotoxic mechanisms and liver pathogenesis in human."
28545106
2017
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.
26489516
2015
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Recently, circulating microRNAs (miRNAs) such as miR-122 and miR-192 have emerged as promising biomarkers of liver injury in preclinical species and in DILI patients.
25359176
2015
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity.
25693865
2015
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
MiR-122 as a biomarker also has the potential to bridge results in in vitro experiments to in vivo animal models and human samples using the same assay, and to link findings from clinical studies in determining the relevance of in vitro models being developed for the study of drug-induced liver injury .
25527335
2015
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
22363424
2012
×
Entrez Id:
406906
Gene Symbol:
MIR122
MIR122
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Circulating microRNAs as potential markers of human drug-induced liver injury.
22045675
2011
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
21741958
2011
×
Entrez Id:
2875
Gene Symbol:
GPT
GPT
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure.
19481104
2009
×
Entrez Id:
3106
Gene Symbol:
HLA-B
HLA-B
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
HLA-B *5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
19483685
2009
×
Entrez Id:
2944
Gene Symbol:
GSTM1
GSTM1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI , as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women.
18666253
2008
×
Entrez Id:
2944
Gene Symbol:
GSTM1
GSTM1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity.
17465707
2007
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
In conclusion, slow acetylator status of NAT2 was a significant susceptibility risk factor for antituberculosis drug-induced hepatotoxicity ; NAT2 genotyping may be a useful tool for predicting antituberculosis drug-induced hepatotoxicity .
17950035
2007
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota.
16799928
2006
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1 ) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population.
16770646
2006
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
12668988
2003
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
11915035
2002
×
Entrez Id:
2875
Gene Symbol:
GPT
GPT
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats.
145039
1977
×
Entrez Id:
2952
Gene Symbol:
GSTT1
GSTT1
Drug-Induced Liver Disease
0.390
Biomarker
CTD_human
Characterization of chemically induced liver injuries using gene co-expression modules.
25226513
2014
×
Entrez Id:
2952
Gene Symbol:
GSTT1
GSTT1
Drug-Induced Liver Disease
0.390
Biomarker
CTD_human
The GSTT1 homozygous null polymorphism may be a risk factor of antituberculosis drug-induced hepatotoxicity in Caucasians.
18397238
2008
×
Entrez Id:
2952
Gene Symbol:
GSTT1
GSTT1
Drug-Induced Liver Disease
0.390
Biomarker
CTD_human
The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI , as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women.
18666253
2008