Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease: HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.700 Biomarker GENOMICS_ENGLAND Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. 23643382

2013
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease: HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.700 GeneticVariation UNIPROT Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. 23643382

2013
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease: HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.700 Biomarker CTD_human

Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease: HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.700 SusceptibilityMutation CLINVAR

Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C3808981
Disease: HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA 		0.700 CausalMutation CLINVAR

Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET In the present study, we analyzed the expression of the MKP1, MKP2, and MKP3 isoforms in rat brain after electroconvulsive seizure (ECS), considered the most effective treatment for depression. 15496935

2005
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker HPO

Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker BEFREE In BD fibroblasts, DUSP6 knockdown reversed the BD rhythm phenotype, restoring the ability of lithium to increase amplitude in these cells. 27216486

2016
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker PSYGENET Thus, DUSP6 may not only play important roles in the pathogenesis of bipolar disorder, particularly in women, but also affect the therapeutic response to lithium through modulating lithium's effects on intracellular signaling. 22155192

2012
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker BEFREE Thus, DUSP6 may not only play important roles in the pathogenesis of bipolar disorder, particularly in women, but also affect the therapeutic response to lithium through modulating lithium's effects on intracellular signaling. 22155192

2012
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker PSYGENET Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS). 17239488

2007
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker LHGDN The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder. 16491131

2006
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation BEFREE The DUSP6 gene is located on chromosome 12q22-23, which overlaps one of the reported bipolar disorder susceptibility loci. 11032376

2000
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker PSYGENET The DUSP6 gene is located on chromosome 12q22-23, which overlaps one of the reported bipolar disorder susceptibility loci. 11032376

2000
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker BEFREE We found no significant associations with DUSP6 SNPs in men with bipolar disorder or schizophrenia. 22155192

2012
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.310 AlteredExpression BEFREE Functional assays were performed with adenovirus-mediated expression of DUSP6 in glioblastoma cultures. 21499306

2011
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.310 Biomarker CTD_human Functional assays were performed with adenovirus-mediated expression of DUSP6 in glioblastoma cultures. 21499306

2011
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.310 Biomarker CTD_human Functional assays were performed with adenovirus-mediated expression of DUSP6 in glioblastoma cultures. 21499306

2011
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.310 AlteredExpression BEFREE Functional assays were performed with adenovirus-mediated expression of DUSP6 in glioblastoma cultures. 21499306

2011
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0162809
Disease: Kallmann Syndrome
Kallmann Syndrome 		0.300 GermlineCausalMutation ORPHANET Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. 23643382

2013
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0334588
Disease: Giant Cell Glioblastoma
Giant Cell Glioblastoma 		0.300 Biomarker CTD_human Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas. 21499306

2011
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.300 Biomarker CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942

2005
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker PSYGENET In the present study, we analyzed the expression of the MKP1, MKP2, and MKP3 isoforms in rat brain after electroconvulsive seizure (ECS), considered the most effective treatment for depression. 15496935

2005
Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms 		0.300 Biomarker CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942

2005