Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 GeneticVariation UNIPROT Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. 19164855

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker GENOMICS_ENGLAND Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome. 17576055

2008
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker GENOMICS_ENGLAND Furthermore, genetic variation in and around the AKT2 locus is unlikely to contribute significantly to the risk of type 2 diabetes or related intermediate metabolic traits in U.K. populations. 17327441

2007
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 GeneticVariation UNIPROT A family with severe insulin resistance and diabetes due to a mutation in AKT2. 15166380

2004
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker GENOMICS_ENGLAND A family with severe insulin resistance and diabetes due to a mutation in AKT2. 15166380

2004
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker CTD_human

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker GENOMICS_ENGLAND

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker GENOMICS_ENGLAND Overgrowth Syndromes Caused by Somatic Variants in the Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Pathway. 28502730

2017
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 GermlineCausalMutation ORPHANET Activating AKT2 mutation: hypoinsulinemic hypoketotic hypoglycemia. 24285683

2014
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker GENOMICS_ENGLAND Activating AKT2 mutation: hypoinsulinemic hypoketotic hypoglycemia. 24285683

2014
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 GermlineCausalMutation ORPHANET An activating mutation of AKT2 and human hypoglycemia. 21979934

2011
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 GeneticVariation UNIPROT An activating mutation of AKT2 and human hypoglycemia. 21979934

2011
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker GENOMICS_ENGLAND Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. 17327441

2007
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker GENOMICS_ENGLAND A family with severe insulin resistance and diabetes due to a mutation in AKT2. 15166380

2004
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker CTD_human

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C3278384
Disease: HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY 		0.700 Biomarker GENOMICS_ENGLAND

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Biomarker CTD_human Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance. 19075277

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker CTD_human Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance. 19075277

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GenomicAlterations CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GenomicAlterations CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.460 CausalMutation CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 GenomicAlterations CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 GenomicAlterations CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.380 GenomicAlterations CGI

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.380 GenomicAlterations CGI