Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression BEFREE To determine the role of ACC1 in cancer and normal liver cells, ACC1 expression was downregulated in human hepatoma Hep G2 cells and the rat liver cell line BRL 3A using RNA interference technology, which demonstrated that silencing of ACC1 significantly suppressed the cell viability in the two cell lines. 30816537

2019
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker BEFREE These studies highlight the importance of DNL and dysregulation of AMPK-mediated ACC phosphorylation in accelerating HCC and the potential of ACC inhibitors for treatment. 30244972

2019
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression BEFREE The enhanced lipogenesis in HCCs is characterized by an increased expression of rate-limiting enzyme acetyl-coenzyme A carboxylase alpha (ACCα). 26698170

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 GeneticVariation BEFREE Two SNPs in ACACA gene were significantly associated with overall survival of HCC patients. 25826294

2015
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 GeneticVariation BEFREE Although we did not find any significant results in total analysis (all p>0.05), our stratified data showed that SNP rs9912300 in ACLY gene was significantly associated with overall survival of HCC patients with lower AFP level and SNP rs11871275 in ACACA gene was significantly associated with overall survival of HCC patients with higher AFP level. 25735330

2015
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker CTD_human Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. 21147110

2011
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 GeneticVariation BEFREE However, haplotype ACAC was only found to be associated with increased risk of CRC. 31740231

2020
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 Biomarker BEFREE Among 311 patients with CRC [51.5% male, 25.3% black, 18.7% Hispanic, 32.0% Asian, and mean age at diagnosis 58.1 years (SD 10.3)] 61.4% had advanced ACC stage 3-4 CRC at diagnosis. 28040840

2017
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 GeneticVariation UNIPROT

Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0018801
Disease: Heart failure
Heart failure 		0.310 Biomarker BEFREE What Is New in Heart Failure Management in 2017? Update on ACC/AHA Heart Failure Guidelines. 29667019

2018
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.310 Biomarker BEFREE What Is New in Heart Failure Management in 2017? Update on ACC/AHA Heart Failure Guidelines. 29667019

2018
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0018801
Disease: Heart failure
Heart failure 		0.310 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.310 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure 		0.300 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation 		0.300 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0268603
Disease: Acetyl-CoA: carboxylase deficiency
Acetyl-CoA: carboxylase deficiency 		0.300 Biomarker CTD_human

Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.210 Biomarker BEFREE Moreover, NI alleviated hepatic steatosis, possibly by significantly interacting with HFD to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5). 29309075

2018
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.210 Biomarker RGD Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. 16485039

2006
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Biomarker RGD Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. 16485039

2006
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.200 Biomarker RGD These studies suggest that pharmacological inhibition of Acc1 and -2 may be a novel approach in the treatment of NAFLD and hepatic insulin resistance. 16485039

2006
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker BEFREE Blood pressure and the new ACC/AHA hypertension guidelines. 31521481

2020
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker BEFREE Approximately 17.0% and 40.1% of participants met the respective definitions of hypertension according to Joint National Committee 7 (JNC7) and 2017 American College of Cardiology/American Heart Association (ACC/AHA) Hypertension Guideline. 31382808

2020
Entrez Id: 31
Gene Symbol: ACACA
ACACA
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker BEFREE Impact of the new criteria of the ACC/AHA on the diagnostic prevalence of hypertension. 31481243

2020