Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.500 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human These data indicate that APE1/Ref-1 is a key regulator of survivin and a potentially viable target in prostate cancer. 29541389

2018
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker CTD_human APE/Ref-1 was upregulated in HCC cells consistent with the strong expression of APE/Ref-1 in HCC tissue microarray. 25109342

2014
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human We determined whether polymorphisms in XRCC1 and APE1 increase the risk of prostate cancer. 16406883

2006
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.380 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.350 Biomarker CTD_human c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. 27602772

2016
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0025202
Disease: melanoma
melanoma 		0.350 Biomarker CTD_human These observations suggested that intracellular Ref-1 levels played an important role in sensitization of melanoma cells to apoptosis. 16373707

2005
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.300 Biomarker CTD_human APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. 29541389

2018
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.300 Biomarker CTD_human Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes. 22262564

2012
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C1449861
Disease: Micronuclei, Chromosome-Defective
Micronuclei, Chromosome-Defective 		0.300 Biomarker CTD_human Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: a pilot study. 22245109

2012
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C1449862
Disease: Micronuclei, Genotoxicant-Induced
Micronuclei, Genotoxicant-Induced 		0.300 Biomarker CTD_human Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: a pilot study. 22245109

2012
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.300 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0235874
Disease: Disease Exacerbation
Disease Exacerbation 		0.300 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0022333
Disease: Jacksonian Seizure
Jacksonian Seizure 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0036572
Disease: Seizures
Seizures 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0234535
Disease: Clonic Seizures
Clonic Seizures 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0270844
Disease: Tonic Seizures
Tonic Seizures 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0270846
Disease: Epileptic drop attack
Epileptic drop attack 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0422850
Disease: Seizures, Somatosensory
Seizures, Somatosensory 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0422852
Disease: Seizures, Auditory
Seizures, Auditory 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0422853
Disease: Olfactory seizure
Olfactory seizure 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0422854
Disease: Gustatory seizure
Gustatory seizure 		0.300 Biomarker CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108

2010