Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Biomarker BEFREE We previously reported that urocortin 2 (Ucn2) gene transfer increases heart function in mice with heart failure with reduced ejection fraction. 31676153

2020
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Biomarker BEFREE We previously reported that urocortin 2 (Ucn2) gene transfer increases heart function in mice with heart failure with reduced ejection fraction. 31676153

2020
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Biomarker BEFREE Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. 30003813

2019
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Biomarker BEFREE Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. 30003813

2019
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Biomarker BEFREE Urocortin-2 (Ucn-2) has shown promising therapeutic effects in experimental and clinical left ventricular heart failure (HF). 29584808

2018
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Biomarker BEFREE Urocortin-2 (Ucn-2) has shown promising therapeutic effects in experimental and clinical left ventricular heart failure (HF). 29584808

2018
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 AlteredExpression BEFREE Moreover, plasma Ucn2 levels were 7.5-fold higher in patients with heart failure compared to those in healthy controls. 28550160

2017
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Biomarker BEFREE All three Ucns exert salutary hemodynamic, neurohormonal and renal effects in experimental heart failure and recent clinical trials have demonstrated hemodynamic benefits of Ucn2 administration. 28887029

2017
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Biomarker BEFREE All three Ucns exert salutary hemodynamic, neurohormonal and renal effects in experimental heart failure and recent clinical trials have demonstrated hemodynamic benefits of Ucn2 administration. 28887029

2017
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 AlteredExpression BEFREE Moreover, plasma Ucn2 levels were 7.5-fold higher in patients with heart failure compared to those in healthy controls. 28550160

2017
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Biomarker BEFREE Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. 25760560

2015
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Biomarker BEFREE Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. 25760560

2015
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.360 Therapeutic CTD_human Ucn2 has marked and beneficial hemodynamic, hormonal, and renal effects in experimental HF. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.360 Therapeutic CTD_human Ucn2 has marked and beneficial hemodynamic, hormonal, and renal effects in experimental HF. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0003123
Disease: Anorexia
Anorexia 		0.300 Biomarker CTD_human Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. 17627984

2007
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Therapeutic CTD_human Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Therapeutic CTD_human Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure 		0.300 Therapeutic CTD_human Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation 		0.300 Therapeutic CTD_human Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. 16330704

2005
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0009319
Disease: Colitis
Colitis 		0.210 Biomarker BEFREE TXYF was also found to ameliorate symptoms of DSS-induced colitis in mice and to promote mucosal repair like Ucn2. 29713130

2018
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0009319
Disease: Colitis
Colitis 		0.210 Biomarker RGD The role of Ucn 2 and CRF-R2 was then examined in a rat model of chemically-induced colitis. 17586086

2007
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.100 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement 		0.100 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker BEFREE LC cells were enriched in the recurrent chimera COL7A1-UCN2, which potentially affected cancer stem cell transition, promoted epithelial-mesenchymal transition in LC, and resulted in poorer prognoses. 29499655

2018
Entrez Id: 90226
Gene Symbol: UCN2
UCN2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker BEFREE In addition, our data support an association between anti-SRP autoantibody positivity and malignancy, which calls for further investigation. 29453582

2018