Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis. 30805717

2019
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation BEFREE Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. 31346172

2019
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker BEFREE The altered regulation of PVRL2 may increase the susceptibility AD patients to HSV and other virus infections of the brain. 30319691

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker BEFREE To better understand the biological mechanisms underlying the regulation of AD biomarkers, and its relation to AD, we examined the association between 36 selected single nucleotide polymorphisms (SNPs) and AD biomarkers Aβ1-42, t-tau, and p-tau in CSF in a cohort of 672 samples (571 AD patients and 101 controls) collected within 10 European consortium centers.Our results highlighted five genes, APOE, LOC100129500, PVRL2, SNAR-I, and TOMM40, previously described as main players in the regulation of CSF biomarkers levels, further reinforcing a role for these in AD pathogenesis. 30320580

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker CTD_human The results of analyses confirmed strong associations of genetic variants from well-known genes APOE, TOMM40, PVRL2 (NECTIN2), and APOC1 with AD. 29107063

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker CTD_human To better understand the biological mechanisms underlying the regulation of AD biomarkers, and its relation to AD, we examined the association between 36 selected single nucleotide polymorphisms (SNPs) and AD biomarkers Aβ1-42, t-tau, and p-tau in CSF in a cohort of 672 samples (571 AD patients and 101 controls) collected within 10 European consortium centers.Our results highlighted five genes, APOE, LOC100129500, PVRL2, SNAR-I, and TOMM40, previously described as main players in the regulation of CSF biomarkers levels, further reinforcing a role for these in AD pathogenesis. 30320580

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker CTD_human The altered regulation of PVRL2 may increase the susceptibility AD patients to HSV and other virus infections of the brain. 30319691

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 Biomarker BEFREE The results of analyses confirmed strong associations of genetic variants from well-known genes APOE, TOMM40, PVRL2 (NECTIN2), and APOC1 with AD. 29107063

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. 29274321

2018
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT Transethnic genome-wide scan identifies novel Alzheimer's disease loci. 28183528

2017
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. 24755620

2014
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. 23419831

2014
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930

2012
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Genome-wide association analysis of age-at-onset in Alzheimer's disease. 22005931

2012
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease. 22832961

2012
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. 21627779

2011
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. 21379329

2011
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASCAT A comprehensive genetic association study of Alzheimer disease in African Americans. 22159054

2011
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB A comprehensive genetic association study of Alzheimer disease in African Americans. 22159054

2011
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.440 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011