×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Targeted ErbB3 Cancer Therapy: A synergistic approach to effectively combat cancer .
31846731
2020
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
GeneticVariation
BEFREE
ERBB3 mutations in cancer : biological aspects, prevalence and therapeutics.
31519989
2020
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
To aid the development of anti-HER3 antibodies as cancer therapeutics, we combined antibody engineering and functional genomics screens to identify putative mechanisms of resistance or synthetic lethality with antibody-mediated anti-proliferative effects.
30523157
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
HER3 and -4 immunoreactivity was not associated with WHO malignancy grade, nor with recurrence or survival in adjusted analyses.
31400925
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Ligand-Independent EGFR Activation by Anchorage-Stimulated Src Promotes Cancer Cell Proliferation and Cetuximab Resistance via ErbB3 Phosphorylation.
31615015
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
AlteredExpression
BEFREE
We hypothesized that EGFR downstream of STAT3 participates in HER3 expression because STAT3 contributes to cancer stemness and survival of EGFR-TKI resistant cancers .
31619200
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
AlteredExpression
BEFREE
Binding specificity and cellular processing were studied in HER3 -expressing human cancer cell lines BxPC-3 and DU145.Biodistribution was studied 3 h p.i. in Balb/c nu/nu mice bearing BxPC-3 xenografts.Mice were imaged 3 h p.i. using microPET/CT.
30832342
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Overall, these results reinforce the potential of HER3 -targeted affibodies for cancer therapy and establish treatment of ovarian cancer as an application where multivalent HER3 ligands may be useful.
30949858
2019
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Collectively, these data show that progressive functional gains by HER2 can increase its repertoire of activities such as the activation of PI3K and overcome its dependency on HER3 .<b>Significance:</b> The intrinsic ability of HER2 to activate PI3K correlates with increased HER2 expression and can supplant the dependency upon HER3 for growth in HER2-amplified cancers .<i>Cancer Res; 78(13); 3645-58.©2018 AACR</i>.
29760043
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Together, these findings suggest that cross-talk between HER3 and HPV oncoproteins promotes resistance to PI3K inhibitors and that cotargeting HER3 and PI3K may be an effective therapeutic strategy in HPV(+) tumors.<b>Significance:</b> These findings suggest a new therapeutic combination that may improve outcomes in HPV(+) head and neck cancer patients.<i>Cancer Res; 78(9); 2383-95.©2018 AACR</i>.
29440171
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
These results highlight tumor microenvironment regulation of targeted inhibitor resistance in WT/WT melanoma and provide a rationale for combining MEK inhibitors with anti-ErbB3/ErbB2 antibodies in patients with WT/WT cutaneous melanoma, for whom there are no effective targeted therapy options.<b>Significance:</b> This work suggests a mechanism by which NRG1 regulates the sensitivity of WT NRAS/BRAF melanomas to MEK inhibitors and provides a rationale for combining MEK inhibitors with anti-ErbB2/ErbB3 antibodies in these tumors.<i>Cancer Res; 78(19); 5680-93.©2018 AACR</i>.
30115691
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
AlteredExpression
BEFREE
In recent times, ErbB3 overexpression has been linked to drug resistance and progression of various diseases, especially cancer .
28889394
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
GeneticVariation
BEFREE
Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers : Entering the back door.
29413684
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Upon AUY922 treatment, higher radioconjugate uptake was detected in treated MCF-7 xenografts, correlating with an AUY922-induced HER3 upregulation concomitant with an increase in IGF-1Rβ expression.<b>Conclusions:</b> These data underline the potential of HER3 -based PET imaging to noninvasively provide information about HER3 expression and to identify patients not responding to targeted therapies due to HER3 recovery.<i>Clin Cancer Res; 24(8); 1853-65.©2018 AACR</i>.
29437790
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
GeneticVariation
BEFREE
Knocking down HER3 from ovarian and colorectal cancers with endogenous HER3 mutations abrogated cancer cell proliferation.
29963236
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3 , plays an important regulatory role in the expression and function of ErbB3 , but there is no agreement as to whether Ebp1 also has an ErbB3 -independent function in cancer and how it might contribute to tumorigenesis.
30076717
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
AlteredExpression
BEFREE
Studies on the underlying mechanism implicate HER3 expression as a major cause of treatment failure in cancer therapy.
30109175
2018
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
A comprehensive review of heregulins, HER3 , and HER4 as potential therapeutic targets in cancer .
29179520
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Targeting HER3 with siRNAs or KTN3379 significantly inhibited the growth of HPV<sup>+</sup> cell lines and PDXs.<b>Conclusions:</b> This study uncovers a direct relationship between HPV infection and HER3 in HNSCC and provides a rationale for the clinical evaluation of targeted HER3 therapy for the treatment of HPV<sup>+</sup> patients.<i>Clin Cancer Res; 23(12); 3072-83.©2016 AACR</i>.
27986750
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
In this review, we highlight the role of HER3 in cancer and, more specifically, in lung cancer.
28000159
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
HER3 is an important therapeutic target in cancer treatments.
28235665
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Overexpression of human epidermal growth factor receptor 3 (HER3 ) is involved in resistance to several therapies for malignant tumours .
28230065
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Human epidermal growth factor receptor 3 (HER3 ) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy.
28899363
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Because both ERBB2 and ERBB3 are targets for treating an array of cancer types, it is important to examine the consequences of receptor inhibition in human keratinocytes.
28805349
2017
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
Malignant Neoplasms
0.400
Biomarker
BEFREE
Expression of human epidermal growth factor family member 3 (HER3 ), a critical heterodimerization partner with EGFR and HER2, promotes more aggressive biology in breast and other epithelial malignancies .
28680745
2017