Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 GeneticVariation BEFREE This meta-analysis showed that the MCP-1-2518-A allele confers susceptibility to Asian patients with RA and European patients with CD. 26318885

2016
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 GeneticVariation BEFREE Subgroup analysis by disease subtype suggested the -A2518G polymorphism in MCP-1 had a protective effect against Crohn's disease (OR 0.69, 95% CI 0.58-0.81, P = 0.000), but not against ulcerative colitis. 25620350

2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 Biomarker CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567

2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 AlteredExpression BEFREE MCP-1 plasma levels in CD and UC patients were similar to those in HCs (P=0.38), irrespective of disease activity, or MCP-1 genotypes. 20125127

2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 Biomarker BEFREE Resistin, interleukin-6, and monocyte chemotactic protein-1 were not specifically induced in CD but were associated with unspecific inflammation. 16775490

2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 Biomarker BEFREE MCP-1 concentration in tissue homogenates was analyzed in mucosal biopsy specimens of 31 patients with Crohn's disease and 48 controls by enzyme-linked immunosorbent assay, and the correlation with an endoscopic macroscopic score was analyzed. 12904997

2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.360 Biomarker BEFREE In contrast, inflamed mucosa from patients with ulcerative colitis or Crohn's disease contained multiple cells immunoreactive for MCP-1, including spindle cells, mononuclear cells, and endothelial cells. 7806062

1995