Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker BEFREE Studies suggest that leptin, an adipokine, has a neuroprotective role against Alzheimer's disease (AD) and that cytokines are associated with inflammatory processes and dementia. 30150062

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 AlteredExpression BEFREE We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence. 29758945

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker BEFREE Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia. 28421328

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker BEFREE In addition to this evidence linking leptin to neural plasticity and function, observational studies evaluating leptin-sufficient humans have also demonstrated direct correlation between blood leptin levels and brain volume and inverse associations between circulating leptin and risk for the development of dementia. 26881138

2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker BEFREE Some authors proposed that leptin evaluation might be a better predictor of dementia than traditional anthropometric measures. 26279362

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Therapeutic CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255

2010