DisGeNET - a database of gene-disease associations

Source: ALL

Disease: Diabetes Mellitus, Experimental ×

Gene: LEP ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	3952
Gene Symbol:	LEP

LEP

CUI:	C0011853
Disease:	Diabetes Mellitus, Experimental

Diabetes Mellitus, Experimental

0.500

Biomarker

CTD_human

Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice.

28242381

2017

Entrez Id:	3952
Gene Symbol:	LEP

LEP

CUI:	C0011853
Disease:	Diabetes Mellitus, Experimental

Diabetes Mellitus, Experimental

0.500

ModifyingMutation

RGD

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.

20695765

2011

Entrez Id:	3952
Gene Symbol:	LEP

LEP

CUI:	C0011853
Disease:	Diabetes Mellitus, Experimental

Diabetes Mellitus, Experimental

0.500

Biomarker

RGD

A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin.

19491210

2009