DisGeNET - a database of gene-disease associations

Source: ALL

Disease: Kidney Failure, Chronic ×

Gene: SERPINE1 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	5054
Gene Symbol:	SERPINE1

SERPINE1

CUI:	C0022661
Disease:	Kidney Failure, Chronic

Kidney Failure, Chronic

0.510

Therapeutic

RGD

An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure.

26903149

2016

Entrez Id:	5054
Gene Symbol:	SERPINE1

SERPINE1

CUI:	C0022661
Disease:	Kidney Failure, Chronic

Kidney Failure, Chronic

0.510

Biomarker

CTD_human

Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure.

19420110

2009

Entrez Id:	5054
Gene Symbol:	SERPINE1

SERPINE1

CUI:	C0022661
Disease:	Kidney Failure, Chronic

Kidney Failure, Chronic

0.510

AlteredExpression

BEFREE

Thus, progression of chronic renal failure may be promoted by PAI-1 up-regulation induced by uremic toxins.

12675842

2003