Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE The levels of CD34/KDR-positive endothelial progenitor cells, CD133/KDR-positive endothelial progenitor cells, and vascular endothelial growth factor were higher in patients with cirrhosis ± hepatocellular carcinoma than in healthy controls (P = 0.017, P < 0.001 and P < 0.001, respectively). 31790004

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE The levels of CD34/KDR-positive endothelial progenitor cells, CD133/KDR-positive endothelial progenitor cells, and vascular endothelial growth factor were higher in patients with cirrhosis ± hepatocellular carcinoma than in healthy controls (P = 0.017, P < 0.001 and P < 0.001, respectively). 31490422

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) and von Willebrand factor (VWF) are associated with the pathophysiology of liver cirrhosis and HCC through their roles in hypercoagulability; they are also associated with angiogenesis <i>via</i> vascular endothelial growth factor (VEGF). 31139312

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 GeneticVariation BEFREE The occurrence of allele A and SNP A>C VEGF gene (-2578) might predict illness progression from healthy to CH, LC or HCC and LC to HCC. 28837651

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE VEGF could be a potential biomarker for HCC, while AFP could be used to distinguish between patients with HCC and cirrhosis or HCV. 26782388

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 AlteredExpression BEFREE i) Serum VEGF levels were higher in patients with progressive disease than those in patients with a partial response or stable disease. ii) VEGF levels were higher in patients with alcoholic LC than those in patients with hepatitis C-related or hepatitis B-related LC. iii) VEGF levels were higher in stage IVB patients than those in patients with stage III or IVA disease. iv) VEGF levels were significantly higher in patients with giant or confluent multinodular tumors than those in patients with multiple discrete nodules. v) Serum VEGF levels were higher in patients with vascular invasion than in patients without vascular invasion. 25862879

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE VEGF was assayed for HCC group (123), liver cirrhosis group (210), and control group (50) by enzyme-linked immunosorbent assay (ELISA). 24687551

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 AlteredExpression BEFREE We found that vasohibin-1 and VEGF are up-regulated, in mesentery and liver, in cirrhotic and precirrhotic portal hypertensive rats and cirrhosis patients. 24390792

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 AlteredExpression BEFREE The tissue transcript levels of VEGF, HIF-1α and endostatin were found to be significantly higher in HCC in comparison to cirrhosis and chronic hepatitis. 24057240

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE Vascular endothelial growth factor (VEGF) was elevated in liver cirrhosis, but the amounts remained unchanged in the transition from liver cirrhosis to HCC. 23970062

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 GeneticVariation BEFREE Our results confirm that carriers with the C allele in the VEGF-A gene are more frequent in HCC versus LC (p=0.039), suggesting that this SNP may predispose to the development of HCC. 21319995

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 GeneticVariation BEFREE Characteristic genotypes of vascular endothelial growth factor are susceptible to ascites in patients with cirrhosis. 19589268

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker LHGDN Vascular endothelial growth factor (VEGF) and its soluble receptors: sVEGF-R1, sVEGF-R2 were measured in plasma of 78 patients with liver cirrhosis by ELISA.Results. 18656381

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker BEFREE There was a gradient of VEGF-165 between hepatic and femoral veins in both HCC and cirrhosis. 17244253

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker LHGDN Angiogenesis in chronic liver disease. 17786144

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker LHGDN Immunohistochemical assessment of angiogenesis in hepatocellular carcinoma and surrounding cirrhotic liver tissues. 15742396

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker LHGDN Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor. 14669345

2003

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 Biomarker CTD_human Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. 11981751

2002

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.400 AlteredExpression BEFREE We observed over expression of VEGF mRNA and protein in HCC compared with cirrhosis or normal liver. 11115828

2001