Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker BEFREE Greater than 85% of the transport-impaired PiZ variant of human alpha 1-antitrypsin is retained within transfected mouse hepatoma cells and is subjected to intracellular degradation (Le, A., Graham, K., and Sifers, R.N.(1990) J. Biol.Chem.265, 14001-14007). 1530934

1992
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker BEFREE In this study, we show that there is time-dependent and saturable internalization of alpha 1-AT-elastase and alpha 1-AT-trypsin complexes in human hepatoma HepG2 cells. 2211587

1990
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker BEFREE In addition, the apparent sizes of native factor I, transferrin, and alpha-1-antitrypsin secreted by the three hepatoma lines differed due to differences in postsynthetic processing. 6327681

1984
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker BEFREE Our study also showed that human alpha-1-AT gene product can be processed for secretion in the rodent hepatoma cellular environment. 6801664

1982