Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE In addition, the presence and load of somatic hypermutation (SHM) within the rearranged IG heavy variable (IGHV) gene occurring as during B-cell development of germinal center and post-germinal center lymphomas may hamper appropriate primer binding leading to false-negative results. 30779036

2019

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE IGH@ proto-oncogene translocation is a common oncogenic event in lymphoid lineage cancers such as B-ALL, lymphoma and multiple myeloma. 31243274

2019

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE In the present study, we assessed by FISH whether exposure to low concentrations (0.1 μm, 72 hours) of permethrin and malathion induce aberrations in KMT2A and IGH genes, which are involved in the etiology of leukemia and lymphoma. 29741206

2018

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE To explore the relationship between IgH gene rearrangement and orbital MALT (mucose-associated lymphoid tissue) lymphoma removal operation prognosis, and to quantify the effect of IgH gene rearrangement on primary orbital MALT lymphoma prognosis. 28678330

2017

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein-Barr virus-associated lymphomas. 26991077

2016

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Specifically, the diagnosis of a relapsed DLBCL with acquisition of IGH-CCND1 was rendered for case 1, molecularly confirmed by the detection of identical monoclonal IGH rearrangements between the initial diagnostic DLBCL and relapse lymphoma. 25596256

2015

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE IGH@ evaluation of follow-up biopsies for these cases were nonclonal (7) or clonal, but with a different clone from the prior biopsy (1); follow-up of the 8 patients showed no evidence of lymphoma (mean, 37.8 mo). 24897069

2014

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE The BIOMED-2 protocols were used to determine the clonality of IGH gene rearrangements in patients with lymphoma. 25481017

2014

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas. 22944768

2013

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE In patients with B-cell chronic lymphocytic leukemia, both flow-cytometry as well as RQ-PCR are equally suitable for MRD assessment as long as a sensitivity of ≤10(-4) shall be achieved.MRD diagnostics targeting the IgH gene is complex and requires extensive knowledge and experience because the junctional regions of each lymphoma have to be identified before the patient-specific RQ-PCR assays can be designed for MRD monitoring. 23296964

2013

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Both primary breast lymphoma and lymphoma with concurrent BCL2-IGH and MYC translocations are rare and are primarily seen in adult patients. 21491965

2012

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE FISH screening of a population-based cohort of B-cell lymphomas from a prospective trial for the treatment of lymphoma in childhood (BFM-NHL) identified additionally a follicular lymphoma Grade 3/diffuse large B-cell lymphoma with IGH-CBFA2T3/ACSF3 juxtaposition. 22420028

2012

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Patients with neoplasms characterized by extra MYC signals plus IGH@BCL2 (n=6) or MYC rearrangement with extra BCL2 signals (n=2) had overall survival ranging from 1.7 to 49 months, similar to patients with MYC/BCL2 lymphomas. 22002575

2012

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas. 21790530

2011

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE Overall our findings demonstrate that C. psittaci-negative ocular adnexal EMZL exhibit biased usage of IGHV families and genes with evidence for intraclonal heterogeneity and antigen selection in multiple tumors, implicating B-cell receptor-mediated antigen stimulation in the pathogenesis of these lymphomas. 22216179

2011

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Two showed an additional IGH-CCND1/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas). 20960563

2011

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Therefore, current investigations using melting curve analysis are being developed 1213.In this study, three different techniques were compared to evaluate the suitability of LightCycler PCR with HRM as the clonal diagnostic tool for IgH gene rearrangement in B-cell non-Hogdkin lymphoma, i.e. thermocycler PCR followed by heteroduplex analysis and PAGE, GeneScan analysis and LightCycler PCR with HRM. 20482846

2010

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation LHGDN Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas. 18538438

2008

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE The heterogeneous representation of IGHV genes in HIV-NHL may be related to specific pathways of antigen stimulation, or to differences in host's immune dysregulation and lymphoma histogenesis. 18556404

2008

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE We have comprehensively investigated the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain (IGH) gene locus, in a large series of gastric DLBCL. 18445693

2008

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 AlteredExpression BEFREE A related issue, relevant not only to lymphoma development but also to normal controls on IGH gene expression, is the stage, during B lymphocyte development, at which the 3'RR is capable of activating MYC expression. 17639584

2007

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Thus, the molecular detection of a clonal rearrangement of the IGH gene may support the diagnosis of a malignant lymphoma infiltrating the bone marrow. 17560629

2007

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE A single-tube multiplex PCR targeted IGH and lymphoma-specific translocations in DNA extracted from 180 frozen lymphoid tissues and DNA bound to FTA cards from 192 fresh tissues and 137 aspirates. 17378729

2007

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 GeneticVariation BEFREE Polymerase chain reaction (PCR)-based analysis, employed for detecting immunoglobulin heavy chain (IgH) gene rearrangements, has become a diagnostic tool widely used in the investigation of B-cell lymphomas, but the overall sensitivity of these methods does not exceed 80%, notably in germinal center (GC) and post-GC B-cell origin lymphomas. 16677778

2006

Entrez Id: 3492
Gene Symbol: IGH
IGH
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.200 Biomarker BEFREE In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma. 16765702

2006