Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis. 27918083

2018

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Myxovirus resistance protein A (MxA) polymorphism is associated with IFNβ response in Iranian multiple sclerosis patients. 28386647

2018

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Soluble Receptor for Advanced Glycation End Products (sRAGE) is Up-Regulated in Multiple Sclerosis Patients Treated with Interferon β-1a. 29617694

2018

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Interferon-β 1a (IFN-β 1a) is a common strategy therapy for multiple sclerosis (MS) with unknown mechanisms. 28433998

2018

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Biological monitoring of IFN-β therapy in Multiple Sclerosis. 25596967

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b. 26458124

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Our findings confirmed the lack of association between HLA-DRB1 and clinical response to IFNβ among MS patients as previous studies had done. 25824849

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Less Frequent and Less Severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients with at Least One Allele Bearing the G>C Polymorphism at Position -174 of the IL-6 Promoter Gene. 26285213

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE These biomarkers may have prognostic value for long-term MS evolution, and their transcription levels in blood decline during treatments with GNbAC1, which has also been reported in patients administered reference MS drugs such as natalizumab or interferon-β. 26376649

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Besides, receiver operating characteristic analysis revealed that the baseline expression of TRAIL-α in monocytes and T cells, and that of TRAILR-1 in monocytes and CD4+ T cells, showed a predictive value of the clinical response to IFNβ therapy, pointing to a role of TRAIL system in the mechanism of action of IFNβ in MS that will need further investigation. 25736057

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-β treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-β and vitamin D. 26037530

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Interferon-β and glatiramer acetate showed the most reliable long-term safety and remain among the first-line disease-modifying therapies for MS worldwide. 26678572

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients. 27020477

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE MxA mRNA expression as a biomarker of interferon beta response in multiple sclerosis patients. 26857498

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Currently, interferon beta (IFNβ) is a common treatment for MS. 25882258

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE The IMPROVE study evaluated subcutaneous IFNb versus placebo in 180 patients with relapsing-remitting MS. 25392319

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Therapeutic CTD_human Thirty Dutch relapsing remitting (RR) MS patients treated with IFNβ-1a received high dose vitamin D<sub>3</sub> supplementation and 23 patients received placebo during a period of 48weeks. 27806875

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Pharmacogenomics of interferon-β in multiple sclerosis: what has been accomplished and how can we ensure future progress? 25524087

2016

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE Even though anti-interferon beta (IFNβ) antibodies are the main determinants of IFNβ bioactivity loss and Myxovirus-resistance protein A (MxA) is the most established marker of IFNβ biological activity in IFNβ-treated multiple sclerosis patients, their usefulness in the routine clinical practice is still debated. 24733382

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE IFN-β is widely used in the treatment of multiple sclerosis, yet the mechanism facilitating its efficacy remains unclear. 25888642

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by interferon-β: a longitudinal study in multiple sclerosis patients. 25169051

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Levels of mRNA for dopaminergic receptor D₅ in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis. 25468276

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Particularly, the study took into account patients undergoing pharmacological therapy with interferon-beta or natalizumab and patients never treated since first-time diagnosed for MS. 25115502

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients. 25551576

2015

Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE We performed a genome-wide association study in interferon-β (IFNβ)-treated MS patients followed by validation in 3 independent cohorts. 25914168

2015