|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
Furthermore, we performed low/high resolution typing of HLA-DRB1 and HLA-DQB1 alleles to detect associations of these loci with MG subtypes.
|
30741378 |
2019 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
MuSK-MG is strongly associated with HLA-DRB1*14, HLA-DRB1*16 and HLA-DQB1*05.
|
30929252 |
2019 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
The meta-analysis showed that HLA DQB1*05, DRB1*14 and DRB1*16 were strongly associated with an increased risk of MuSK-MG (P < .0001), whereas HLA DQB*03 was less frequent in MuSK patients compared with healthy controls (P < .05).
|
29736936 |
2018 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
This study provides novel information about HLA susceptibility alleles in Norwegian juvenile MG where HLA-DRB1*04:04 was associated with prepubertal onset.
|
29036181 |
2017 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
AlteredExpression |
BEFREE |
Furthermore IFNG-AS1 influenced the expression levels of CD40L and CD4<sup>+</sup> T cells activation in MG patient partly depend on effecting the HLA-DRB1 expression.
|
28822831 |
2017 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
HLA-C*05, DRB1*01, and DRB1*11 were higher in patients with ocular MG.
|
27802446 |
2017 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
HLA-DRB1*14 and DQB1*05 were associated with MuSK+MG, therefore these alleles may play important roles in developing MuSK+MG across the races.
|
27000234 |
2016 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
Within the MG patients, there was a strong positive association between HLA-B*4601-DRB1*0901 and juvenile ocular MG patients, and the value of odds ratios (OR) decreased as the disease became more severe and the age of onset increased.
|
25953150 |
2015 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98).
|
26605347 |
2015 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
Among other MG subgroups and with less significance, DRB1*0101 DQA1*0101 DQB1*05 haplotype (P=0.016, OR=3.68) had positive association with pure ocular MG, and DRB1*03 DQA1*0501 DQB1*0201 haplotype (P=0.024) had negative association with thymomatous MG.
|
26671138 |
2015 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
GWASCAT |
A genome-wide association study of myasthenia gravis.
|
25643325 |
2015 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
The HLA DRB1*16-DQB1*05 (OR 2.9) haplotype was found to be associated with MuSK MG (P < 0.05).
|
25070808 |
2015 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
The DRB1*03, DRB1*04, DQB1*02, and DQB1*03 alleles also could be predisposing genetic factors for MG in the Tunisian population.
|
22521184 |
2013 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
Moreover, HLA-DRB1(∗)03 appears to have a distinguishing role for this disease subgroup compared to early-onset and AChR-MG.
|
23993985 |
2013 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population.
|
22590574 |
2012 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients.Sixty-two MG patients had thymoma.
|
21074862 |
2011 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
These results indicate that HLA-DRB1(*)09 might be positively associated and DRB1(*)08 negatively associated with MG in the northern Han Chinese population.
|
21924912 |
2011 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
The top three ranked genes, HLA-G, TAP2 and HLA-DRB1, are implicated in autoimmune diseases, while TAP2 is associated with SNPs characteristic for MG.
|
18851734 |
2008 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
Hyper-spliced transcripts spanned several categories, including the tumorogenic ERBB4 tyrosine kinase receptor and the connective tissue growth factor CTGF, as well as the immune function-related histocompatibility gene HLA-DRB1 and interleukin (IL)19, two muscle-specific collagens and one myosin heavy chain gene; intriguingly, a putative new exon was discovered in the MG-involved acetylcholinesterase ACHE gene.
|
18545673 |
2008 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
DRB1*0901 and DQB1*0303 tended to be more frequently detected in the six MG patients with AA than in the 82 patients without it.
|
15958099 |
2005 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
Tests to identify alleles with the strongest association to MG in our patients detected DRB1*13 and B*38 as possible predisposing secondarily associated alleles in patients with hyperplasia.
|
14700596 |
2004 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
These date suggest that LG type of MG may present a particular subset of childhood-onset MG, which is associated with the specific HLA subtypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303.
|
15003812 |
2004 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
No statistically significant difference was observed in the overall prevalences of DRB1 and DQB1 alleles between MG patients and healthy controls, even when the patients and controls were stratified on the basis of their gender.
|
11535234 |
2001 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
GeneticVariation |
BEFREE |
Analysis of the TNF-B*1, C4A*Q0, C4B*1, DRB1*03 supratype and its recombinants showed that the MHC region between C4 and TNF might contain genes that influence susceptibility to MG in females.
|
11574100 |
2001 |
|
HLA-DRB1
|
Myasthenia Gravis
|
0.200 |
Biomarker |
BEFREE |
HLA class II alleles in the DQA1, DQB1, DRB1, and DPB1 genes were investigated in Japanese patients with myasthenia gravis (MG) by digestion of polymerase chain reaction amplified DNAs with allele specific restriction endonucleases (PCR-RFLP).
|
7749041 |
1994 |