Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.020 GeneticVariation BEFREE Here, we show that treatment with the dual phosphoinositide-3-kinase (PI3K)/AKT and mTOR inhibitor BEZ235 attenuated PI3K/AKT and mTOR signaling, as well as induced cell-cycle growth arrest and apoptosis of the cultured human JAK2-V617F-expressing HEL92.1.7 (HEL), UKE1 cells, and primary CD34+ myelofibrosis (MF)-MPN cells. 23445613

2013
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.020 AlteredExpression BEFREE In addition to dysregulated JAK/STAT signaling, activation of the AKT/mTOR pathway occurs in myelofibrosis, a myeloproliferative neoplasm with no approved therapies. 21725052

2011