|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
Notably, following the combined therapy all patients showed induction/enhancement of T-cell responses by CD107 degranulation or IFNγ ELISPOT assay against patient-specific tumor IGHV sequences.
|
31171545 |
2019 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
The clonal DNA IGHV sequence of the tumor was aligned and compared with the closest germline sequence and homology percentage was calculated.
|
28838616 |
2017 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
Immunoglobulin IGHV genes carry imprints of clonal tumor history, delineating somatic hypermutation (SHM) events that generally occur in the germinal center (GC).
|
25929340 |
2015 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
The tumor immunoglobulin heavy chain variable region was more frequently unmutated in CLL cells of LR patients, and the mevalonate pathway, which generates Vγ9Vδ2 TCR ligands, was more active in unmutated CLL cells.
|
22932792 |
2012 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
Clinical trials of IgHV protein vaccines against lymphoma have demonstrated induction of tumor-specific cytotoxic T lymphocyte (CTL) responses.
|
17517179 |
2007 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
In the other two patients, a similar VH band pattern was observed and also was compared using direct sequencing, which demonstrated sequence differences between tumors from the two sites.
|
15372481 |
2004 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
Biomarker |
BEFREE |
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias.
|
1700749 |
1990 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
GeneticVariation |
BEFREE |
We have previously shown that the cytogenetic breakpoints of one t(14;14)(q11;q32) chromosome and two inv(14)(q11;q32) chromosomes in T-cell tumors from AT and non-AT patients join the T-cell receptor alpha chain locus, at chromosome band 14q11, with a region(s) at 14q32 centromeric of the immunoglobulin heavy chain variable region (VH) gene IGHV.
|
3194418 |
1988 |
|
IGHV3OR16-7
|
Neoplasms
|
0.090 |
GeneticVariation |
BEFREE |
The immunoglobulins secreted by these cell lines reacted variably with a panel of anti-idiotypic antibodies, indicating that the tumor was heterogeneous; however, one antibody, 4D6, reacted strongly with the product of all the heterohybridomas. cDNA for the immunoglobulin heavy chain variable-region genes expressed in these heterohybridomas was cloned and sequenced.
|
3496601 |
1987 |