|
CHRFAM7A
|
Schizophrenia
|
0.400 |
AlteredExpression |
BEFREE |
Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area.
|
29305655 |
2018 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
AlteredExpression |
BEFREE |
Expression of CHRNA7 and CHRFAM7A mRNA was measured in the postmortem prefrontal cortex in more than 700 subjects, including patients with schizophrenia, bipolar disorder, major depression, and normal comparison subjects.
|
26206074 |
2015 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Exon 6 of CHRFAM7A harbors a 2-bp deletion polymorphism, CHRFAM7AΔ2bp, which is also associated with schizophrenia.
|
25056953 |
2014 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
The association between a 2bp deletion in CHRFAM7A and schizophrenia suggested that this duplicate gene might contribute to cognitive impairment.
|
21718690 |
2011 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
AlteredExpression |
BEFREE |
Differentiating nicotine- versus schizophrenia-associated decreases of the alpha7 nicotinic acetylcholine receptor transcript, CHRFAM7A, in peripheral blood lymphocytes.
|
19082523 |
2009 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Recent evidence suggests that CHRFAM7A is a locus with a possible role in schizophrenia and cognitive functioning.
|
19149910 |
2009 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
Biomarker |
PSYGENET |
We conclude that the presence of the 2 bp polymorphism at the CHRFAM7A locus may have a functional significance in schizophrenia.
|
19631623 |
2009 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
We conclude that the presence of the 2 bp polymorphism at the CHRFAM7A locus may have a functional significance in schizophrenia.
|
19631623 |
2009 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Previous associations of endophenotypes of schizophrenia with the 2 bp deletion might therefore be due to the orientation of the duplicon containing CHRFAM7A.
|
18545269 |
2008 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Several previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype.
|
17113175 |
2007 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
LHGDN |
Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type.
|
17192894 |
2007 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
AlteredExpression |
BEFREE |
CHRNA7 and CHRFAM7A mRNA levels were measured in postmortem prefrontal cortex (donated by the Stanley Foundation) from subjects with schizophrenia, bipolar disorder and unaffected controls (n = 35 each).
|
16889592 |
2006 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
A 2bp deletion in exon 6 of CHRFAM7A, which disrupts the hybrid gene and has previously been associated with P50 deficit, was genotyped in 251 individuals from the Maudsley Family Study of schizophrenia.
|
17012698 |
2006 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
LHGDN |
Characterization of allelic variants at chromosome 15q14 in schizophrenia.
|
16417613 |
2006 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
No significant association was seen for schizophrenia and bipolar disorder by genotype or allele overall for either polymorphism, but a mildly significant association by genotype (P = 0.04) was observed for absence of CHRFAM7A when the sample was analyzed as a single psychosis phenotype.
|
16823804 |
2006 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
LHGDN |
These observations indicate that episodic memory function is a schizophrenia endophenotype and implicate the CHRFAM7A/CHRNA7 locus in modulating its function.
|
17012698 |
2006 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Identification of molecular variants at the promoter region of the human alpha 7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia.
|
15531077 |
2004 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
Biomarker |
BEFREE |
These markers are within 1 cM from CHRNA-7, the site previously implicated in schizophrenia.
|
11803512 |
2001 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
GeneticVariation |
BEFREE |
Recent reports have strongly linked markers near the alpha-7 nicotinic cholinergic receptor subunit gene on human chromosome 15q13-q14 to a sensory gating deficit common in schizophrenics, and have shown positive though non-significant results linking this region to the primary phenotype of schizophrenia in a sample of North American families.
|
10893497 |
2000 |
|
CHRFAM7A
|
Schizophrenia
|
0.400 |
Biomarker |
BEFREE |
In summary, we did not find any evidence that the alpha 7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia.
|
9754620 |
1998 |