Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Molecular cloning, characterization and expression analysis of (B-cell lymphoma-2) Bcl-2 in the orange-spotted grouper (Epinephelus coioides). 28606801

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. 28984827

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE MYC translocation is a defining feature of Burkitt lymphoma (BL), and the new category of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 translocations, and occurs in 6% to 15% of diffuse large B-cell lymphomas (DLBCLs). 28288039

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE The B-cell lymphoma 2 (BCL2) family of proteins comprise key regulators of apoptosis and are implicated in the pathogenesis of many malignancies, including lymphomas and leukaemias. 28449207

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Inhibition of anti-apoptotic BCL-2 (B-cell lymphoma 2) has recently emerged as a promising new therapeutic strategy for the treatment of a variety of human cancers, including leukemia. 28074072

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE No statistical differences in the apoptosis rate of A549/DDP cell line in the early stage were found among the three groups (all P > 0.05), but the late-stage apoptosis rate in the anti-miR-196a group was significantly higher than that in the blank group and the miR-NC group (both P < 0.05); The expressions of human multidrug resistance 1 (MDR1), multidrug resistance protein 1 (MRP1), excision repair cross-complementation 1 (ERCC1), survivin, and B cell lymphoma 2 (Bcl-2) decreased significantly while RhoE increased significantly in the anti-miR-196a group than the blank group and the miR-NC group (all P < 0.05). 26376998

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. 27513891

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Clinical significance of co-expression of MYC and BCL2 protein in aggressive B-cell lymphomas treated with a second line immunochemotherapy. 26390147

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The impact of MYC proto-oncogene, basic helix-loop-helix (MYC) translocations (with or without additional rearrangements involving the B-cell lymphoma 2 [BCL2] or BCL6 genes) on the response to salvage therapy and survival in patients with diffuse large B-cell lymphoma (DLBCL) who experience primary treatment failure is not well defined. 28749548

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE As a well-known oncogene, B cell lymphoma-2 (BCL-2) can promote cancer cell survival through preventing their apoptosis. 26311051

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Immunohistochemical staining of proliferation markers antigen KI-67 (Ki67) and proliferating cell nuclear antigen (PCNA), as well as a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay demonstrated a decrease of tumor proliferation and an increase of apoptosis, which was associated with the modulation of B-cell lymphoma 2 (Bcl-2) family activating the caspase cascade in the P. urinaria-treated mice. 27776427

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Mature B-cell lymphomas with concurrent rearrangements of MYC and BCL2 (more rarely BCL6), "double-hit lymphomas" (DHLs), form a heterogeneous group. 26727417

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE B-cell lymphomas from Mdm2(Tg);p73(+/-) mice retain the remaining p73 allele, exhibit elevated levels of the antiapoptotic protein Bcl2 and thus dampen apoptosis. 25915849

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Translocations affecting both MYC and BCL2 are associated with a poor prognosis in diffuse large B-cell lymphomas. 25284491

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Double-hit B-cell lymphoma is a common designation for a group of tumors characterized by concurrent translocations of MYC and BCL2, BCL6, or other genes. 26573234

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE The incidence and prognostic role of MYC and BCL2 rearrangements in mature B-cell lymphomas have been extensively studied, except the infrequent mantle cell lymphoma (MCL). 26517511

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The apoptotic response was due to the up-regulation of pro-apoptotic protein, Bax, and down-regulation of antiapoptotic protein, B cell lymphoma 2 (Bcl-2). 26703449

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Higher levels of B-cell lymphoma-2 (Bcl-2) and tissue factor (TF) but lower apoptotic rate were found in hippocampus of CPZ-treated schizophrenic patients compared with non-antipsychotic treated controls. 26592196

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Bcl-2 (B cell lymphoma/leukemia gene-2) is the first proto-oncogene recognized to function by inhibiting programmed cell death/apoptosis. 26091803

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE After different concentrations of UDCA treatment, the mRNA and protein expressions of caspase-3, caspase-8, caspase-9, Bax, Fas/FasL (Fas ligand), TRAIL (TNF-related apoptosis-inducing ligand), DR4 (death receptor 4) and DR5 (death receptor 5) were increased in HSC-3 cells, and mRNA and protein expressions of Bcl-2 (B-cell lymphoma 2), Bcl-xL (B-cell lymphoma-extra large), XIAP (X-linked inhibitor of apoptosis protein), cIAP-1 (cellular inhibitor of apoptosis 1), cIAP-2 (cellular inhibitor of apoptosis 2) and survival were decreased. 25951128

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Double-hit lymphomas (DHLs) are collectively defined as B-cell non-Hodgkin lymphomas harboring rearrangements of MYC as well as B-cell lymphoma 2 (BCL2) and/or B-cell lymphoma 6 (BCL6). 26565895

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE The anti-apoptotic B-cell lymphoma 2 (BCL-2) family proteins, including BCL-2, BCL-X(L), and MCL-1 have been characterized as key survival factors in multiple cancer types. 26134786

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. 26657288

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The suppression of REV3L expression enhanced the sensitivity of cervical cancer cells to cisplatin, and the overexpression of REV3L conferred resistance to cisplatin as evidenced by the alteration of apoptosis rates, and significantly expression level changes of anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2), myeloid cell leukemia sequence 1 (Mcl-1) and B-cell lymphoma-extra large (Bcl-xl) and proapoptotic Bcl-2-associated x protein (Bax). 25781640

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE B-cell lymphoma-2 (BCL-2) prevents apoptosis and its overexpression could promote cancer cell survival. 26132559

2016