Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia 		0.030 AlteredExpression BEFREE Furthermore, micro-injection of the NF-κB inhibitor pyrrolidine dithiocarbamate into PVN in MI rats, significantly inhibited the activation of NF-κB and further reduced the expression of IL-1β and NGF in the PVN, finally blunting sympathetic hyperinnervation in the heart, moreover, the blockade of NF-κB in the PVN reduced the incidence of ventricular arrhythmias (VAs). 31175933

2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia 		0.030 Biomarker BEFREE This study aimed to investigate whether exogenous interleukin-1β (IL-1β) could aggravate VA through regulating LSG remodeling. 28826800

2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia 		0.030 Biomarker BEFREE At day 5 post-MI, high-speed optical mapping of transmembrane potential and intracellular Ca<sup>2+</sup> in isolated hearts revealed that IL-1β inhibition improved conduction velocity, reduced action potential duration dispersion, improved intracellular Ca<sup>2+</sup> handling, decreased transmembrane potential and Ca<sup>2+</sup> alternans magnitude, and reduced spontaneous and inducible ventricular arrhythmias. 28111350

2017