|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma.
|
30948344 |
2020 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
MRI Features Associated with TERT Promoter Mutation Status in Glioblastoma.
|
30644143 |
2019 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations occur in the majority of glioblastoma, bladder cancer (BC), and other malignancies while the ETS family transcription factors GABPA and its partner GABPB1 activate the mutant TERT promoter and telomerase in these tumors.
|
31802036 |
2019 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Eribulin inhibited the growth of 4 TERT promoter mutation-harboring glioblastoma cell lines in vitro at subnanomolar concentrations.
|
31099446 |
2019 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
|
30187121 |
2018 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
These results highlight the critical role of GABPβ1L in enabling immortality in TERT promoter mutant glioblastoma.
|
30205050 |
2018 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
Biomarker |
BEFREE |
Here we report the genetic landscape of TERTp<sup>WT</sup>-IDH<sup>WT</sup> glioblastoma and identify SMARCAL1 inactivating mutations as a novel genetic mechanism of ALT.
|
29802247 |
2018 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations were highly frequent in glioblastoma (83.9%), urothelial carcinoma (64.5%), oligodendroglioma (70.0%), medulloblastoma (33.3%) and hepatocellular carcinoma (31.4%).
|
25843513 |
2015 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Patients with IDH1/2 wild-type gliomas and glioblastoma-like genomic alterations, including gain on chromosome arm 7q (+7q), loss on chromosome arm 10q (-10q), TERT promoter mutation and oncogene amplification, displayed the worst outcome.
|
25783747 |
2015 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.
|
25681309 |
2015 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
AlteredExpression |
BEFREE |
In thyroid cancers, the presence of TERT promoter mutations (when occurring together with BRAF mutations) is significantly associated with higher TERT mRNA expression, and in glioblastoma we find a trend for increased telomerase expression in cases harbouring TERT promoter mutations.
|
23887589 |
2013 |
|
LOC110806263
|
Adult Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Originally described in melanoma, the mutations in TERT promoter have been shown to be common in certain other tumor types that include glioblastoma, hepatocellular carcinoma, and bladder cancer.
|
24101484 |
2013 |