Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells. 31410187

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma. 30943404

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE By promoting the adaptation to non-adherent conditions, mechanisms driven by HIF-1α may considerably contribute to the biology and aggressiveness of glioblastoma. 31128911

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma because it causes drug delivery deficiencies and the induction of hypoxia-inducible factor-1α in tumor cells. 31252311

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma. 30569180

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Our findings elucidate a mechanism whereby LSD1 controls senescence in Glioblastoma tumor cells through the regulation of HIF-1α, and we propose the novel defined LSD1/HIF-1α axis as a new target for the therapy of Glioblastoma tumors. 30951900

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 GeneticVariation BEFREE The findings of the current study demonstrate presence of the IDH1 R132H mutation in primary human glioblastoma cell lines with upregulated HIF-1α expression, downregulating c-MYC activity and resulting in a consequential decrease in miR-20a, which is responsible for cell proliferation and resistance to standard temozolomide treatment. 29625108

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE CCL20 was secreted in a hypoxia-dependent manner from astrocytes and busted the hypoxic induction of HIF-1α in glioblastoma cells. 29535421

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE While HIF1α has been widely studied in cancer, HIF2α offers a potentially more specific and appealing target in glioblastoma given expression in glioma stem cells and not normal neural progenitors, activation in states of chronic hypoxia and expression that correlates with glioma patient survival. 30089425

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide. 30013951

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE The aforementioned results demonstrate that hypoxia could induce enhancements of migration and invasion by activating PI3K/Akt/mTOR pathway by targeting HIF-1α in human glioblastoma U87 cells, which provide a theoretical basis for the treatments of GBM by targeting the PI3K/Akt/mTOR/HIF-1α pathway. 30371540

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Through bioinformatics analysis, the high expression of HIF-1α, MCT1 or MCT4 indicate a poor prognosis in glioblastoma. 29928884

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Clinical positron emission tomography studies using radiolabeled Cu-ATSM have shown that Cu-ATSM accumulates in glioblastoma and its uptake is associated with high hypoxia-inducible factor-1α expression. 29154146

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Therefore, our findings uncover a hypoxia-induced negative feedback mechanism that maintains high activity of HIF-1 and cell mobility in human glioblastoma. 29860315

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Taken together, these results suggest that DT at clinically achievable concentration functions as an inhibitor of HIF-1α, worthy of further investigations in the therapy of glioblastoma. 28410215

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Furthermore, the liposomes made better modulation of glioblastoma microenvironment such as the down-regulation of CD31-positive tumor vessels and HIF-1α expression. 28252970

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Role of AHR and HIF-1α in Glioblastoma Metabolism. 28318896

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Hif-1α also positively correlates with H19 in human glioblastoma samples depending on PTEN status. 28327666

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE FGFR1 Induces Glioblastoma Radioresistance through the PLCγ/Hif1α Pathway. 26896280

2016

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Under hypoxic conditions, HIF-1α protein levels in the glioblastoma cell lines increased, primarily localizing into the nucleus similar to glioblastoma tissues. 27472259

2016

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Because hypoxia-inducible factor 1α (HIF-1α) is the major mediator of hypoxia-regulated cellular control, inhibition of this transcription factor may reduce glioblastoma growth. 25423275

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression BEFREE Reduced PDH activity in U87 glioblastoma and NHA IDH1 mutant cells was associated with relative increases in PDH inhibitory phosphorylation, expression of pyruvate dehydrogenase kinase-3, and levels of hypoxia inducible factor-1α. 26045167

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Focusing on inhibiting the signaling pathways, which are associated with hypoxia-mediated maintenance of glioblastoma stem cells or the knockdown of the hypoxia-inducible factor 1-alpha (HIF1α), may help to the develop new target-specific treatments. 26559087

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Given the role of HIF-1α in cell migration, we conclude that the attenuation of HIF-1α-dependent glioblastoma cell infiltration contributes to the better outcomes of patients with IDH1-mutant gliomas. 25511738

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker BEFREE Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. 26083570

2015