Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Clinicopathological and prognostic value of CD24 expression in breast cancer: a meta-analysis. 28315505

2018

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Fluorescence Activated Cell Sorting (FACS) analysis showed the presence of a variable fraction of CD44(+)CD24(-) cells in 25 out of 25 breast cancer samples. 26546432

2017

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress. 25641732

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells. 26797459

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Our results suggest that CD24 overexpression is an independent unfavourable prognostic factor in breast cancer, especially for luminal A and TNBC subtypes, and CD24 may be a promising therapeutic target for specific subtypes of breast cancer. 26444008

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE EMT leads to generation of mesenchymal-like breast cancer cells with stem cell-like characteristics and a CD44(+)CD24(-/low) expression pattern. 26384399

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Second, we overlap all the intrinsic subtypes across cHER2+ BC to obtain a continuum of mixed phenotypes in which one extreme exhibits a high identity with ALDH+ CSCs and the other extreme exhibits a high preponderance of CD44+CD24-/low CSCs. 26474458

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Exposure of MCF-7 and SUM159 human breast cancer cells to pharmacological concentrations of DATS (2.5 and 5 μm) resulted in dose-dependent inhibition of bCSC, as evidenced by a mammosphere assay and flow cytometric analysis of aldehyde dehydrogenase 1 (ALDH1) activity and the CD44(high)/CD24(low)/epithelial specific antigen-positive fraction. 27129776

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells (BCSCs). 25826085

2016

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE MKP1 overexpression was also detected in irradiated HER2-positive breast cancer stem-like cells (HER2(+)/CD44(+)/CD24(-/low)) isolated from a radioresistant breast cancer cell population after long-term radiation treatment. 25377473

2015

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer. 25541438

2015

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Characterization of CD44+CD24-Cancer stem cell(CSC) derived from breast cancer cells indicated that CSC rapidly formed mammospheres and had potent tumorigenicity in vivo. 25301732

2015

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Furthermore, the expression of SMO and Gli1 was positively correlated with the expression of CD44+ / CD24-, and the expression of SMO and Gli1 in CD44+ / CD24- tissues was associated with a significantly shorter OS (overall survival) and DFS (disease-free survival) in breast cancer patients receiving chemotherapy. 26201092

2015

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE In MCF10DCIS cells treated with vitamin D compounds (1α25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced. 25445919

2015

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE The CD44(+)/CD24(-/low) and ALDH1+ phenotypes were identified in 16% and 15% of the familial breast cancer cases, respectively, and associated with high-tumor grade, a high-mitotic count, and component features of the medullary type of breast cancer. 23813303

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells. 24754246

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE CD24 polymorphisms cannot predict pathologic complete response to anthracycline- and taxane-based neoadjuvant chemotherapy in breast cancer. 24393851

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Here, we identify two T-ISC subsets within this population in triple negative breast cancer (TNBC) lines and dissociated primary breast cancer cultures: CD44(+) CD24(low+) subpopulation generates CD44(+) CD24(neg) progeny with reduced sphere formation and tumourigenicity. 23982961

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Investigations in endocrine-resistant breast cancer cell lines and SRC-1(-/-)/PyMT mice confirmed a role for SRC-1 and HOXC11 in downregulation of CD24 and PAWR. 24648347

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE We demonstrate that sorcin depletion in MDA-MB-231 breast cancer cells reduces the pool of CD44(+)/CD24(-) and ALDH1(high) cancer stem cells (CSCs) as well as mammosphere-forming capacity. 24337682

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE Interestingly, a protective role of the CD24 rs3838646 polymorphism was found in the risk of breast cancer, but lack of statistical significance (del allele vs. TG allele: OR = 0.89; 95 % CI, 0.79-1.01; P OR = 0.063; del/del vs. 24894672

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Cytoplasmic YB1 was detected more often in carcinomas of ductal type (p = 0.002), of higher nuclear grade (p < 0.001), with lack of ER expression (p = 0.002), positive expression of p53 and Ki67 (p = 0.002 and p = 022, respectively), and with present CD44(+)/CD24(-/low) breast cancer stem cells (p = 0.001), while its association with bcl-2 was found to be inverse (p = 0.042). 24075827

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Mammosphere formation frequency and CD44(high)/CD24(low)/ESA+ and/or ALDH1+ populations in cultured MCF-7 (estrogen receptor-positive) and SUM159 (triple-negative) human breast cancer cells were decreased significantly in the presence of plasma achievable concentrations of BITC. 23661606

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE The induction of EMT did not enhance tumour-initiating capacity but, instead, conferred a CD44(+)/CD24(-/low) phenotype as well as cell proliferation, migration, and resistance to doxorubicin and radiation on breast cancer cell lines. 24755887

2014

Entrez Id: 100133941
Gene Symbol: CD24
CD24
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE HER2-expressing BCSCs (HER2(+)/CD44(+)/CD24(-/low)) were isolated from radiation-treated breast cancer MCF7 cells and in vivo irradiated MCF7 xenograft tumors. 23091114

2013