Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE ZHX2 could inhibit proliferation and promote apoptosis of lung cancer cells by inhibiting p38MAPK signaling pathway. 31683461

2020
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition. 31285551

2019
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression BEFREE Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer. 29662630

2018
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE PHLPP negatively regulates PI3K/Akt and RAF/RAS/' signaling activation, which is crucial in development, growth, and proliferation of lung cancer. 26463718

2015
Entrez Id: 22882
Gene Symbol: ZHX2
ZHX2
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE Although >90% of BRAF mutations in melanoma involve codon 599 (57 of 60), 8 of 9 BRAF mutations reported to date in NSCLC are non-V599 (89%; P < 10(-7)), strongly suggesting that BRAF mutations in NSCLC are qualitatively different from those in melanoma; thus, there may be therapeutic differences between lung cancer and melanoma in response to RAF inhibitors. 12460918

2002