Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.020 Biomarker BEFREE The objective of this project is to assess the prognostic value of detecting immune markers (IL-10, IL-4, TGFβ1, IFNγ, IL-6, and TNFα), the expression of HPV-HR E6/E7 proteins, and the viral load at the cervical level with respect to the persistence or clearance of HR-HPV infection, and the regression or progression of a cervical premalignant lesion. 30453958

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.020 GeneticVariation BEFREE Our results reveal that -308 TNFA AA individuals are at increased risk of invasive cervical cancer development and more important, that the risk is significantly increased for the progression from premalignant lesion to invasive cancer. 24197984

2014

Entrez Id: 7431
Gene Symbol: VIM
VIM
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 AlteredExpression BEFREE Vimentin was stably expressed in oral premalignant lesion derived cells (vimentin negative) and various transformation related phenotypic assays were performed. 30189187

2018

Entrez Id: 51561
Gene Symbol: IL23A
IL23A
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 AlteredExpression BEFREE Since Th17 cells are prominent at the premalignant lesion state and their levels are supported by IL-23, studies used mice that were IL-23 receptor deficient (IL-23R KO) to determine the requirement for IL-23 signaling in the immunological and clinical status of mice with premalignant oral lesions. 29664967

2018

Entrez Id: 7295
Gene Symbol: TXN
TXN
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE These findings suggest that paeonol may be used as an adjuvant therapy for SASP factor-mediated EMT in premalignant lesion. 28801702

2018

Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE Sessile serrated adenoma/polyp (SSA/p) is a premalignant lesion in the colon and rectum. 30510949

2018

Entrez Id: 811
Gene Symbol: CALR
CALR
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE Sessile serrated adenoma/polyp (SSA/p) is a premalignant lesion in the colon and rectum. 30510949

2018

Entrez Id: 151516
Gene Symbol: ASPRV1
ASPRV1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE These findings suggest that paeonol may be used as an adjuvant therapy for SASP factor-mediated EMT in premalignant lesion. 28801702

2018

Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE Silencing of RASSF1A and concurrent NF-κB activation demonstrate that a subset of FTH shares epigenetic changes and downstream signaling events associated with malignant lesions, suggesting that FTH may have the potential to be a premalignant lesion. 25229773

2014

Entrez Id: 56254
Gene Symbol: RNF20
RNF20
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE We propose that genomic instability triggered by Bre1 deficiency may be an important early step that precedes acquisition of an invasive phenotype, as we find decreased levels of BRE1A/B and dimethylated H3K79 in testicular seminoma and in the premalignant lesion in situ carcinoma. 22354749

2012

Entrez Id: 57509
Gene Symbol: MTUS1
MTUS1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 AlteredExpression BEFREE In this study, we first confirmed that the down-regulation of MTUS1/ATIP was a frequent event in oral tongue squamous cell carcinoma (OTSCC) and the premalignant lesion (leukoplakia). 22153618

2012

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE (1) Colon epithelia in a mouse model with LOI of Igf2 showed increased sensitivity to IGF1R blockade and abrogation of premalignant lesion development in LOI(+) mice. 19177016

2009

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE (1) Colon epithelia in a mouse model with LOI of Igf2 showed increased sensitivity to IGF1R blockade and abrogation of premalignant lesion development in LOI(+) mice. 19177016

2009

Entrez Id: 6318
Gene Symbol: SERPINB4
SERPINB4
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE The objectives of this study were to prove the relationship of squamous cell carcinoma antigen 2 (SCCA2) mRNA expression in peripheral blood with non-malignant lesion, premalignant lesion, and carcinoma of the esophagus at the same assay, as well as to evaluate whether or not SCCA2 mRNA expression in peripheral blood may be a biomarker for monitoring the premalignant lesion of the disease. 19125792

2008

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 GeneticVariation BEFREE In this case-control study of 115 oral premalignant lesion (OPL) patients and 230 controls, we genotyped the CCND1 single nucleotide polymorphism (SNP) at the exon 4 splice site (G870A) and determined the association of this SNP with the risk of developing OPLs. 16638786

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 GeneticVariation BEFREE Three (60%) of 5 PTCs and 1 out of 17 benign lesions had BRAF(V600E) mutation (only one false positive case and the definitive pathology showed atypical nodular hyperplasia that could be a premalignant lesion). 17054470

2006

Entrez Id: 7517
Gene Symbol: XRCC3
XRCC3
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 GeneticVariation BEFREE Our results showed no evidence of a relationship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. 16425350

2005

Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 GeneticVariation BEFREE Our results showed no evidence of a relationship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. 16425350

2005

Entrez Id: 4585
Gene Symbol: MUC4
MUC4
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 Biomarker BEFREE Abnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett's oesophageal premalignant lesion associated with an increase in mucin-producing goblet cells and MUC4 mucin gene overexpression. 14583090

2004

Entrez Id: 7039
Gene Symbol: TGFA
TGFA
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 AlteredExpression BEFREE Transgenic mice with ectopic expression of transforming growth factor alpha (TGF-alpha) in the pancreatic acinar cells develop tubular metaplasia, a potential premalignant lesion of the pancreatic ductal epithelium. 11756558

2002

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0850639
Disease: premalignant lesion
premalignant lesion
0.010 GeneticVariation BEFREE In a population-based case-control study in Yangzhong, China, we investigated the relationship between genetic polymorphisms of GSTP1 and susceptibility to gastric cancer and its premalignant lesion, chronic gastritis. 11562107

2001