Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 Biomarker BEFREE Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma. 31575007

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 AlteredExpression BEFREE Also, we found that IR upregulated CBR1 mRNA via Nrf2 activation in HNSCC cells and patients. 30376862

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 Biomarker BEFREE Concordantly, NRF2-associated gene signature is enriched in HNSCC. 24596130

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 AlteredExpression BEFREE Using an integrated genomic analysis and validation methodology we confirm four molecular classes of HNSCC (basal, mesenchymal, atypical, and classical) consistent with signatures established for squamous carcinoma of the lung, including deregulation of the KEAP1/NFE2L2 oxidative stress pathway, differential utilization of the lineage markers SOX2 and TP63, and preference for the oncogenes PIK3CA and EGFR. 23451093

2013
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 CausalMutation CGI