|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
Biomarker |
BEFREE |
<i>SERPINA1</i> gene and AAT protein play an active role in the pathogenesis of lung cancer and not just reflect inflammatory reaction related to cancer development.
|
31487965 |
2019 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
Biomarker |
BEFREE |
Therefore, we believe that proteins like α2 macroglobulin, αmicroglobulin/bikunin, and SERPINA1 could be useful biomarkers for early detection of lung cancer and in monitoring its evolution.
|
31180588 |
2019 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression |
BEFREE |
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.
|
28368395 |
2017 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
Our aim is to know if AAT-deficient carriers have a higher risk of lung cancer in a study performed exclusively in never-smokers.
|
26287318 |
2015 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression |
BEFREE |
The aim of this case-control study was to investigate phenotypes and serum level of AAT in LC.
|
22331720 |
2012 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression |
BEFREE |
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer.
|
22507634 |
2012 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
|
22993338 |
2012 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
Non-MM variants of AAT and ELA2 genotypes with predicted intermediate or high activity could also represent a risk factor for aggressive form of lung cancer associated with extrathoracic metastases.
|
20521180 |
2011 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
Although the association between alpha 1-antitrypsin deficiency (α₁ATD) carriers and lung cancer risk has been found, the effects of α₁ATD carriers and serum alpha 1-antitrypsin (α₁AT) concentration on non-small cell lung cancer (NSCLC) survival remained unclear.
|
21173712 |
2011 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
CYP1A1 haplotypes (in allele order CYP1A1*4, CYP1A1*2C, CYP1A1*2A) CGC and CGT were associated with an increased risk of lung cancer, whereas AAT was associated with decreased lung cancer risk in this population.
|
19608585 |
2010 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study is to test the relationship between alpha1-AT deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients.
|
16501672 |
2006 |
|
SERPINA1
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation |
BEFREE |
Interaction was examined between smoking and each of four factors previously found to be related to AO: alpha-1 antitrypsin (PiZ allele), ABO blood groups (A antigen), ABH non-secretor status, and first degree relationship to a COPD or lung cancer patient.
|
3485586 |
1986 |