Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker BEFREE Therefore, we hypothesized that glucagon increases hepatic LEPR, which is necessary for glucagon-mediated reversal of hepatic steatosis. 31673703

2020
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker BEFREE In the multiple regression analysis leptin, sObR, FLpI, waist-to-hip ratio, HbA1c, lipids, and HOMA-IR correlated independently with HS (P < 0.0001 for all). 30052309

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker CTD_human Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. 29743445

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker BEFREE MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN. 28088781

2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker CTD_human Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice. 25367288

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 GeneticVariation BEFREE The LEPR rs1137100 is also associated with simple steatosis (OR 2.27, 95% CI 1.27-4.08, P = 0.006). 23278404

2013
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker BEFREE The interaction of HOMA2-IR and IL10 was consistent in both races whereas for LEPR and TGF-beta1 the interactions were statistically significant in only one of the racial groups.These results could imply that some IL10,LEPR and TGF-beta1 polymorphisms may modify an association between steatosis and IR. 19401628

2009
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.360 Biomarker BEFREE There was a trend toward lower levels of mRNA encoding the long form of the leptin receptor in hepatic tissue from patients with NASH compared to those with steatosis only. 17294310

2007