Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 GeneticVariation BEFREE Myelofibrotic transformation was more frequent in patients with additional mutations, especially in SF3B1 (p = 0.02) and IDH1/2 (p < 0.0001) although a persistently high or a progressive increase of the JAK2V617F allele burden while receiving cytoreduction was the strongest predictor of MF transformation (HR 10.8, 95% CI 2.4-49.1, p = 0.002). 29181548

2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 Biomarker BEFREE Bone marrow fibrosis and mutations in ASXL1, SRSF2, EZH2, and IDH1/2 have been found to be additional prognostic factors in primary myelofibrosis (PMF). 28948488

2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 GeneticVariation BEFREE Contrarily, DNA methylation genes (DNMT3A, IDH1, IDH2 and TET2) were mutated most often in PV (0·5) and less frequently in ET (0·23) and PMF (0·20), but without reaching statistical significance. 27447873

2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 Biomarker BEFREE The fourth clonal group (including IDH1 and RUNX1) was acquired at sAML transformation and was predominantly absent at sAML remission/relapsed PMF. 25252869

2015
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 Biomarker BEFREE Mutational profiling for ASXL1, EZH2, SRSF2 and IDH identifies PMF patients who are at risk for premature death or leukemic transformation. 23619563

2013
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 GeneticVariation BEFREE We have studied the mutational status of TET2 (complete coding region), ASXL1 (exon12), IDH1 (R132), IDH2 (R140 and R172), and c-CBL (exons 8 and 9) in 62 MPN patients (52 essential thrombocythemia (ET), five polycythemia vera (PV), and five primary myelofibrosis (PMF)) negative for both JAK2 (V617F and exon 12) and MPL (exon 10) mutations. 21904853

2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 GeneticVariation BEFREE In contrast, in both blast-phase PMF (P=0.04) and blast-phase MPN (P=0.01), the presence of an IDH mutation predicted worse survival. 20508616

2010
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.080 GeneticVariation BEFREE IDH1 mutations included R132C (n=4; two post-PMF AML, one post-PV AML and one PMF) and R132S (n=1; post-PMF AML). 20410924

2010