Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE Complicated cases of appendicitis begin to appear when the duration of symptoms exceeds 12 h. Among laboratory tests, C-reactive protein (CRP) value >34 mg/L was the variable with a greater association to appendicitis (odds ratio 9.8). 31482635

2020

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE Pediatric appendicitis scores, white blood cell (WBC) count, absolute neutrophil count (ANC), C-reactive protein (CRP) level, procalcitonin (PCT) and CPT concentrations were higher in the appendicitis group; however, only WBC and ANC were higher in first 24 hours of pain. 31503129

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE A decision tree incorporating the proteins CRP, ferritin, SAA, regulated on activation normal T-cell expressed and secreted (RANTES), monokine induced by gamma interferon (MIG), and PCT demonstrated excellent specificity (0.920) and negative predictive value (0.882) for children with appendicitis. 30918467

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE We therefore believe that before clinically confirming an AA diagnosis, these parameters may be used as diagnostic tools in addition to CBC parameters, CRP levels and radiological imaging studies. 30871739

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE Leucocytes were significantly lower in cases of NA, while C-reactive protein (CRP) level was found to be increased fourfold in cases of severe versus uncomplicated appendicitis and NA. 31041486

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 GeneticVariation BEFREE The combination of low values of pro-ADM and CRP can help to select children with low risk of AA. 30287129

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE Conclusions Only nine of the 208 patients whose pathology reports confirmed appendicitis had healthy values for both CRP and WBC.Many factors affect MPV and PDW. 31183274

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE Clinical findings can differentiate AA and ARCD before imaging studies; nausea/vomiting and anorexia suggest AA, and longer onset-to-visit interval, RLQ pain, previous diverticulitis, and CRP level > 3.0 mg/dL suggest ARCD. 31363467

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE WBC and CRP levels of the AA and PA groups were significantly higher compared to the group with non-specific abdominal pain. 30723978

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE A total of 39.8% of patients with normal CRP and WCC had appendicitis. 31721396

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE Retrospective review was conducted for all patients aged 15 years and under presenting with abdominal pain to our institution in 2017, and data including age, white cell count, neutrophil and lymphocyte count, NLR, C-reactive protein and diagnosis of appendicitis were recorded. 31452301

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 GeneticVariation BEFREE In the work-up of children with suspected acute appendicitis, most surgeons rely on full blood count (92%), C-reactive protein (82%), and abdominal ultrasonography (76%), but rarely on computed tomography scans or magnetic resonance imaging. 30112745

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE Due to atypical symptoms of children, the diagnosis of appendicitis is often delayed, suggesting that the clinicians should be aware of this disease when encountering gastroenteritis patients with elevated WBC and CRP. 30921220

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE CRP and FB are more useful than WBC and ANC to discriminate appendicitis from NSAP in preschool children. 31189186

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE The determination of 20S proteasome concentration in the blood plasma of children with appendicitis and its correlation with CRP. 29264727

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE ROC curve analysis revealed white blood cell count, absolute neutrophils count (ANC), C-reactive protein, total-bilirubin and direct-bilirubin levels as significant factors for diagnosis of AA. 29527857

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE All inflammatory markers, including WBC count, proportion of neutrophils, IG%, and CRP, were statistically different between the appendicitis and nonappendicitis group (P < .01). 29708633

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE CRP and white blood cell count (WBC) were significantly higher in the group with confirmed AA compared to the control group (44.7 <i>vs</i>.6.6, and 13.6 ± 3.9 <i>vs</i>.9.0 ± 3.4, respectively; P < 0.001). 30429680

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE In children with appendicitis (n = 39), leukocytes, platelet count, and the serum levels of C-reactive protein (CRP) and hepcidin were compared to a control group (n = 25) of patients with unspecific abdominal pain. 29273360

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE Recommended cut-off values of NLR and C-reactive protein for severity of appendicitis were determined using receiver operating characteristic analysis (ROC). 28744697

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE Of 281 consecutive patients with histologically proven appendicitis, 24 (8.54%) had normal CRP and WCC on presentation to ED. 27625212

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 AlteredExpression BEFREE The adipose tissue of patients with complicated appendicitis showed significantly higher CRP levels (p = 0.002) compared to patients with uncomplicated appendicitis. 29991774

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE The redistribution of fluid back to the plasma occurred more slowly in the group with appendicitis (P<0.02), in whom higher plasma concentrations of C-reactive protein were measured [median: 38.1 (range 1.8-143.6) vs 1.3 (0.1-159.0) μg ml<sup>-1</sup>; P<0.001]. 30115255

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE The percentage of CRP positivity was higher in the appendicitis group (51.9% vs 15%; p<0.05). 29552432

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0003615
Disease: Appendicitis
Appendicitis
0.100 Biomarker BEFREE The specificity of hyperbilirubinaemia for appendicitis overall was 0.83 with a positive predictive value (PPV) of 0.86, compared with CRP (specificity 0.40, PPV 0.75) and WCC (specificity 0.67, PPV 0.85). 26573997

2017